Serotonin is probably best known for its role in conveying a sense of contentedness and
happiness. It is one of the most unique and pharmacologically complex monoamines in both …

A decreased level of brain 5-hydroxytryptamine (5-HT) has been theorized to be a core
pathogenic factor in depression for half a century. The theory arose from clinical …

Background The serotonin hypothesis of depression proposes that diminished serotonergic
(5-HT) neurotransmission is causal in the pathophysiology of the disorder. Although the …

Serotonin is a major neurotransmitter in the central nervous system (CNS). Dysregulation of
serotonin transmission in the CNS is reported to be related to different psychiatric disorders …

Despite the well-established role of serotonin signaling in mood regulation, causal
relationships between serotonergic neuronal activity and behavior remain poorly …

Abstract Development passes through sensitive periods, during which plasticity allows for
genetic and environmental factors to exert indelible influence on the maturation of the …

Astrocytes orchestrate neural development by powerfully coordinating synapse formation
and function and, as such, may be critically involved in the pathogenesis of …

Maintenance of energy balance requires regulation of the amount and timing of food intake.
Decades of experiments utilizing pharmacological and later genetic manipulations have …

The continuing fascination with serotonin (5‐hydroxytryptamine, 5‐HT) as a nervous system
chemical messenger began with its discovery in the brains of mammals in 1953. Among the …

Abstract Serotonin (5-HT) deficiency occurs in a number of brain disorders that affect
cognitive function. However, a direct causal relationship between 5-HT hypo-transmission …