Fluorescent dyes based on rhodamine derivatives for bioimaging and therapeutics: recent progress, challenges, and prospects

S Zeng, X Liu, YS Kafuti, H Kim, J Wang… - Chemical Society …, 2023 - pubs.rsc.org
Since their inception, rhodamine dyes have been extensively applied in biotechnology as
fluorescent markers or for the detection of biomolecules owing to their good optical physical …

Metal-based photosensitizers as inducers of regulated cell death mechanisms

Y Zhang, BT Doan, G Gasser - Chemical Reviews, 2023 - ACS Publications
Over the last few decades, various forms of regulated cell death (RCD) have been
discovered and were found to improve cancer treatment. Although there are several reviews …

Supramolecular photosensitizer enables oxygen-independent generation of hydroxyl radicals for photodynamic therapy

KX Teng, LY Niu, QZ Yang - Journal of the American Chemical …, 2023 - ACS Publications
The highly oxygen-dependent nature of photodynamic therapy (PDT) limits its therapeutic
efficacy against hypoxic solid tumors in clinics, which is an urgent problem to be solved …

Integration of TADF photosensitizer as “electron pump” and BSA as “electron reservoir” for boosting type I photodynamic therapy

W Chen, Z Wang, M Tian, G Hong, Y Wu… - Journal of the …, 2023 - ACS Publications
Type I photosensitization provides an effective solution to the problem of unsatisfactory
photodynamic therapeutic (PDT) effects caused by the tumor hypoxia. The challenge in the …

Engineering of BODIPY-based theranostics for cancer therapy

Z Mao, JH Kim, J Lee, H Xiong, F Zhang… - Coordination Chemistry …, 2023 - Elsevier
In recent years, BODIPY-based theranostics have increasingly been used in cancer therapy
and have achieved significant success. According to photochemical theories, the optical …

From Low to No O2-Dependent Hypoxia Photodynamic Therapy (hPDT): A New Perspective

M Li, Y Xu, X Peng, JS Kim - Accounts of Chemical Research, 2022 - ACS Publications
Conspectus The advent of photochemical techniques has revolutionized the landscape of
biology and medical sciences. Especially appealing in this context is photodynamic therapy …

Photon-controlled pyroptosis activation (photopyro): an emerging trigger for antitumor immune response

M Li, J Kim, H Rha, S Son, MS Levine… - Journal of the …, 2023 - ACS Publications
Pyroptosis refers to the process of gasdermin-mediated lytic programmed cell death (PCD)
characterized by the release of pro-inflammatory cytokines. Our knowledge of pyroptosis has …

An Activatable Phototheranostic Probe for Anti‐hypoxic Type I Photodynamic‐and Immuno‐Therapy of Cancer

M Zhao, Y Zhang, J Miao, H Zhou, Y Jiang… - Advanced …, 2024 - Wiley Online Library
Photodynamic therapy (PDT), which utilizes type I photoreactions, has great potential as an
effective cancer treatment because of its hypoxia‐tolerant superiority over the commonly …

A cascade strategy boosting hydroxyl radical generation with aggregation-induced emission photosensitizers-albumin complex for photodynamic therapy

Y Li, D Zhang, Y Yu, L Zhang, L Li, L Shi, G Feng… - ACS …, 2023 - ACS Publications
Effective photodynamic therapy (PDT) requires photosensitizers (PSs) to massively generate
type I reactive oxygen species (ROS) in a less oxygen-dependent manner in the hypoxia …

Mechanical stimuli-driven cancer therapeutics

J An, H Hong, M Won, H Rha, Q Ding, N Kang… - Chemical Society …, 2023 - pubs.rsc.org
Mechanical stimulation utilizing deep tissue-penetrating and focusable energy sources,
such as ultrasound and magnetic fields, is regarded as an emerging patient-friendly and …