Neural stem cells therapy for ischemic stroke: progress and challenges

T Zhao, T Zhu, L Xie, Y Li, R Xie, F Xu, H Tang… - Translational stroke …, 2022 - Springer
Ischemic stroke, with its high morbidity and mortality, is the most common cerebrovascular
accident and results in severe neurological deficits. Despite advances in medical and …

The role of cGAS-STING signaling in ischemic stroke: From immune response to therapeutic targeting

C Chauhan, RK Kaundal - Drug discovery today, 2023 - Elsevier
Stroke, a debilitating condition with limited treatment options, presents a significant
therapeutic challenge. A comprehensive grasp of stroke pathophysiology is imperative for …

3D‐Printed Microinjection Needle Arrays via a Hybrid DLP‐Direct Laser Writing Strategy

S Sarker, A Colton, Z Wen, X Xu, M Erdi… - Advanced materials …, 2023 - Wiley Online Library
Microinjection protocols are ubiquitous throughout biomedical fields, with hollow
microneedle arrays (MNAs) offering distinctive benefits in both research and clinical settings …

Preconditioning concepts for the therapeutic use of extracellular vesicles against stroke

M Haupt, ST Gerner, HB Huttner… - Stem Cells …, 2023 - academic.oup.com
Various preclinical stroke models have demonstrated the neuroprotective effects of
extracellular vesicles (EVs) obtained from several types of cells, including neurons …

Low-temperature 3D-printed collagen/chitosan scaffolds loaded with exosomes derived from neural stem cells pretreated with insulin growth factor-1 enhance neural …

XY Liu, YH Feng, QB Feng, JY Zhang… - Neural Regeneration …, 2023 - journals.lww.com
There are various clinical treatments for traumatic brain injury, including surgery, drug
therapy, and rehabilitation therapy; however, the therapeutic effects are limited. Scaffolds …

Stem-cell-based therapy: the celestial weapon against neurological disorders

MA Zayed, S Sultan, HO Alsaab, SM Yousof, GI Alrefaei… - Cells, 2022 - mdpi.com
Stem cells are a versatile source for cell therapy. Their use is particularly significant for the
treatment of neurological disorders for which no definitive conventional medical treatment is …

[HTML][HTML] Neural stem cell therapy for brain disease

L Zhao, JW Liu, HY Shi, YM Ma - World journal of stem cells, 2021 - ncbi.nlm.nih.gov
Brain diseases, including brain tumors, neurodegenerative disorders, cerebrovascular
diseases, and traumatic brain injuries, are among the major disorders influencing human …

[HTML][HTML] Stem cell therapy for central nervous system disorders: Metabolic interactions between transplanted cells and local microenvironments

SA Sakowski, KS Chen - Neurobiology of disease, 2022 - Elsevier
Stem cell therapy is a promising and rapidly advancing treatment strategy for a multitude of
neurologic disorders. Yet, while early phase clinical trials are being pursued in many …

[HTML][HTML] Programmed cell death in stem cell-based therapy: Mechanisms and clinical applications

XM Hu, Q Zhang, RX Zhou, YL Wu, ZX Li… - World Journal of Stem …, 2021 - ncbi.nlm.nih.gov
Stem cell-based therapy raises hopes for a better approach to promoting tissue repair and
functional recovery. However, transplanted stem cells show a high death percentage …

Preconditioning with secretome of neural crest-derived stem cells enhanced neurotrophic expression in mesenchymal stem cells

S Karimi-Haghighi, S Chavoshinezhad, A Safari… - Neuroscience …, 2022 - Elsevier
During the last 20 years, stem cell therapy has been considered as an effective approach for
regenerative medicine. Due to poor ability of stem cells to survive following transplantation, it …