Current practice in the use of MEGA-PRESS spectroscopy for the detection of GABA

PG Mullins, DJ McGonigle, RL O'Gorman, NAJ Puts… - Neuroimage, 2014 - Elsevier
There is increasing interest in the use of edited proton magnetic resonance spectroscopy for
the detection of GABA in the human brain. At a recent meeting held at Cardiff University, a …

In vivo magnetic resonance spectroscopy of GABA: a methodological review

NAJ Puts, RAE Edden - Progress in nuclear magnetic resonance …, 2012 - Elsevier
Conclusion MRS has become established as a robust and powerful tool for the investigation
of the inhibitory neurotransmitter GABA. This is a significant success, given the significant …

Gannet: A batch‐processing tool for the quantitative analysis of gamma‐aminobutyric acid–edited MR spectroscopy spectra

RAE Edden, NAJ Puts, AD Harris… - Journal of magnetic …, 2014 - Wiley Online Library
Purpose The purpose of this study is to describe the Gannet toolkit for the quantitative batch
analysis of gamma‐aminobutyric acid (GABA)‐edited MRS data. Materials and Methods …

Contribution of macromolecules to brain 1H MR spectra: Experts' consensus recommendations

C Cudalbu, KL Behar, PK Bhattacharyya… - NMR in …, 2021 - Wiley Online Library
Proton MR spectra of the brain, especially those measured at short and intermediate echo
times, contain signals from mobile macromolecules (MM). A description of the main MM is …

Big GABA: Edited MR spectroscopy at 24 research sites

M Mikkelsen, PB Barker, PK Bhattacharyya, MK Brix… - Neuroimage, 2017 - Elsevier
Magnetic resonance spectroscopy (MRS) is the only biomedical imaging method that can
noninvasively detect endogenous signals from the neurotransmitter γ-aminobutyric acid …

Edited 1H magnetic resonance spectroscopy in vivo: Methods and metabolites

AD Harris, MG Saleh… - Magnetic resonance in …, 2017 - Wiley Online Library
The Proton magnetic resonance (1H‐MRS) spectrum contains information about the
concentration of tissue metabolites within a predefined region of interest (a voxel). The …

The trajectory of cortical GABA across the lifespan, an individual participant data meta-analysis of edited MRS studies

EC Porges, G Jensen, B Foster, RAE Edden, NAJ Puts - Elife, 2021 - elifesciences.org
γ-Aminobutyric acid (GABA) is the principal inhibitory neurotransmitter in the human brain
and can be measured with magnetic resonance spectroscopy (MRS). Conflicting accounts …

GABAB receptor modulation of visual sensory processing in adults with and without autism spectrum disorder

Q Huang, AC Pereira, H Velthuis, NML Wong… - Science translational …, 2022 - science.org
Sensory atypicalities in autism spectrum disorder (ASD) are thought to arise at least partly
from differences in γ-aminobutyric acid (GABA) receptor function. However, the evidence to …

Reduced gamma-aminobutyric acid concentration is associated with physical disability in progressive multiple sclerosis

N Cawley, BS Solanky, N Muhlert, C Tur, RAE Edden… - Brain, 2015 - academic.oup.com
Neurodegeneration is thought to be the major cause of ongoing, irreversible disability in
progressive stages of multiple sclerosis. Gamma-aminobutyric acid is the principle inhibitory …

Impulsivity and aggression in female BPD and ADHD patients: association with ACC glutamate and GABA concentrations

G Ende, S Cackowski, J Van Eijk, M Sack… - …, 2016 - nature.com
Borderline personality disorder (BPD) and attention-deficit-hyperactivity disorder (ADHD)
are both characterized by high impulsivity and difficulties in controlling anger and …