This article summarizes anatomical, neurophysiological, pharmacological, and brain
imaging studies in humans and animals that have provided insights into the neural circuitry …

Benign prostatic hyperplasia (BPH)-associated lower urinary tract symptoms (LUTS) are
highly prevalent in older men. Medical therapy is the first-line treatment for LUTS due to …

Purpose: We investigated the effects of the selective α1A-adrenoceptor antagonist silodosin
on bladder blood flow and bladder function in a rat model of atherosclerosis induced chronic …

Transient receptor potential (TRP) melastatin 8 (TRPM8) is a temperature-sensing ion
channel mainly expressed in primary sensory neurons (A δ-fibers and C-fibers in the dorsal …

What's known on the subject? and What does the study add? Recently, several studies have
suggested that detrusor overactivity (DO) is the result of bladder ischaemia. Hypertension …

Aims Using a rat BOO model, we determined whether α1‐adrenoceptor (AR) antagonists
(silodosin, prazosin) improve the bladder storage function by reducing afferent input from the …

The aim of this study was to systematically review the evidence on the efficacy and safety of
silodosin treatments on lower urinary tract symptoms (LUTS) in men with benign prostatic …

Introduction: Mechanistic, translational and pharmacological studies led to the identification
and discovery of the preferred localization, binding characteristics, structure and functional …

Use of α-androgenic receptor blockers remains a mainstay therapeutic approach for the
treatment of urological diseases. Silodosin is recommended over other α-blockers for the …

Introduction: Silodosin is a new uroselective alpha-blocker with high pharmacological
selectivity for the 1A adrenoceptor. It is an effective and well-tolerated treatment in men with …