Copper is an essential element in cells; it can act as either a recipient or a donor of
electrons, participating in various reactions. However, an excess of copper ions in cells is …

Copper (Cu) is an essential micronutrient but excess Cu is potentially toxic. Its important
propensity to cycle between two oxidation states accounts for its frequent presence as a …

Copper is a required metal nutrient for life, but global or local alterations in its homeostasis
are linked to diseases spanning genetic and metabolic disorders to cancer and …

Copper is an essential trace metal for normal cellular functions; a lack of copper is reported
to impair the function of important copper‐binding enzymes, while excess copper could lead …

Studies have shown that ursolic acid (UA) and empagliflozin (EM) exert therapeutic effects in
the treatment of diabetic nephropathy (DN), but both drugs have disadvantages. This study …

Copper is a fundamental element for the homeostasis of the body. It is the third most
abundant essential transition metal in humans. Changes in the concentration of copper in …

Abstract Type 2 diabetes (T2DM) is a chronic metabolic disorder. Impaired insulin secretion,
enhanced hepatic glucose production, and suppressed peripheral glucose use are the main …

Diabetes Mellitus (DM) is characterized by elevated blood glucose levels (hyperglycemia). It
can occur due to impaired secretion or action of the hormone insulin, which is produced by …

reactive oxygen species (ros) are induced under diabetic conditions and are likely
associated with the development of type 2 diabetes. it is also known that ros production is …

This article reviews recent evidence, much of which has been generated by my group's
research programme, which has identified for the first time a previously unknown copper …