A causal role was recently attributed to inflammation in many malignant diseases, including
breast cancer. The different inflammatory mediators that are involved in this disease include …

The role of chemokines has been extensively analyzed both in cancer risk and tumor
progression. Among different cytokines, CXCR4 and its ligand CXCL12 have been recently …

CCL2 is a chemokine known to recruit monocytes and macrophages to sites of inflammation.
A growing body of research suggests CCL2 is progressively overexpressed in tumor beds …

Tumor cells aberrantly express chemokines and/or chemokine receptors, and some may
promote tumor growth and metastasis. We examined the expression and function of …

Leukocyte infiltration is a cardinal feature of almost all cancers. Chemokines are generally
responsible for eliciting local accumulation of inflammatory cells and they appear to play the …

Metastasis continues to be the leading cause of mortality for patients with cancer. Several
years ago, it became clear that chemokines and their receptors could control the tumor …

Background Macrophages play diverse roles in mammary gland development and breast
cancer. CC-chemokine ligand 2 (CCL2) is an inflammatory cytokine that recruits …

Whereas the accumulation of fibroblasts and macrophages in breast cancer is a well-
documented phenomenon and correlates with metastatic disease, the functional …

The chemokines RANTES (CCL5) and MCP-1 (CCL2) were suggested to contribute,
independently, to breast malignancy. In the present study, we asked if the two chemokines …

In this second review on chemokines, we focus on the polymorphisms and alternative
splicings and on their consequences in disease. Because chemokines are key mediators in …