Human cytomegalovirus (HCMV) reactivation is a major infectious cause of morbidity and
mortality after allogeneic hematopoietic stem cell transplantation (HSCT). HCMV is a …

While CD8+ T cells specific for human cytomegalovirus (HCMV) have been extensively
studied in both healthy HCMV seropositive carriers and patients undergoing …

Immune checkpoint blockade (ICB) of PD-1 and CTLA-4 to treat metastatic melanoma (MM)
has variable therapeutic benefit. To explore this in peripheral samples, we characterized …

We evaluated the safety and activity of autologous T cells expressing NY-ESO-1c259, an
affinity-enhanced T-cell receptor (TCR) recognizing an HLA-A2–restricted NY-ESO …

BACKGROUND Understanding outcomes and immunologic characteristics of cellular
therapy recipients with SARS-CoV-2 is critical to performing these potentially life-saving …

T cells are the central drivers of many inflammatory diseases, but the repertoire of tissue-
resident T cells at sites of pathology in human organs remains poorly understood. We …

Posttransplantation cyclophosphamide (PTCy) effectively prevents graft-versus-host disease
(GVHD), but its immunologic impact is poorly understood. We assessed lymphocyte …

Immunosequencing is a platform technology that allows the enumeration, specification and
quantification of each and every B-and/or T-cell in any biologic sample of interest. Thus, it …

Monitoring antigen-specific T cells is critical for the study of immune responses and
development of biomarkers and immunotherapeutics. We developed a novel multiplex …

Severe infections and their attributable mortality are major complications in recipients of
allogeneic hematopoietic stem cell transplantation (alloSCT). We herein report 236 adult …