Periodontitis is a chronic inflammatory condition of the periodontium involving interactions
between bacterial products, numerous cell populations and inflammatory mediators. It is …

Risk factors play an important role in an individual's response to periodontal infection.
Identification of these risk factors helps to target patients for prevention and treatment, with …

Maintenance of periodontal health or transition to a periodontal lesion reflects the
continuous and ongoing battle between the vast microbial ecology in the oral cavity and the …

Epigenetic mechanisms regulate expression of the genome to generate various cell types
during development or orchestrate cellular responses to external stimuli. Recent studies …

Sites of ongoing inflammation and triggered immune responses are characterized by
significant changes in metabolic activity. Recent studies have indicated that such shifts in …

Epigenetic modifications occur in response to environmental changes and play a
fundamental role in gene expression following environmental stimuli. Major epigenetic …

Epigenetic mechanisms, namely DNA and histone modifications, are critical regulators of
immunity and inflammation which have emerged as potential targets for immunomodulating …

Periodontitis is a chronic infectious disease driven by dysbiosis, an imbalance between
commensal bacteria and the host organism. Periodontitis is a leading cause of tooth loss in …

Background: Periodontitis is a chronic inflammatory disease involving an interplay between
bacteria, inflammation, host response genes, and environmental factors. The manifestation …

Epigenetics as a modifiable risk factor in periodontal diseases has been investigated in light
of the current knowledge of how chronic infection and inflammation can affect gene‐specific …