The management of patients with severe brain injuries and prolonged disorders of
consciousness raises important issues particularly with respect to their therapeutic options …

The growing understanding of the biology of disorders of consciousness has led to a
renaissance in the development of therapeutic interventions for patients with disorders of …

Abstract Background/Objective For patients with disorders of consciousness (DoC) and their
families, the search for new therapies has been a source of hope and frustration. Almost all …

Objective To describe the sensitivity and specificity of Coma Recovery Scale–Revised (CRS-
R) total scores in detecting conscious awareness. Design Data were retrospectively …

Pharmacologic interventions are commonly used to support rehabilitation efforts of patients
with disorders of consciousness (DoC). The 2018 practice guidelines recommend …

Severe brain injury impairs consciousness by disrupting a broad spectrum of
neurotransmitter systems. Emerging evidence suggests that pharmacologic modulation of …

Consciousness is a multifaceted concept, involving both wakefulness, ie, a condition of
being alert that is regulated by the brainstem, and awareness, a subjective experience of …

During 15 years, 23 clinical reports and 6 studies have demonstrated associations between
sub-sedative doses of zolpidem and recoveries from brain damage due to strokes, trauma …

Disorders of consciousness (DOCs) include coma, vegetative state (VS), and minimally
conscious state (MCS). Coma is characterized by impaired wakefulness and consciousness …

Coma is a medical and socioeconomic emergency. Although underfunded, research on
coma and disorders of consciousness has made impressive progress. Lesion-network …