The Drosophila brain contains a relatively simple circuit for forming Pavlovian associations,
yet it achieves many operations common across memory systems. Recent advances have …

LTP is the most intensively studied cellular model of the memory and generally divided at
least two distinct phases as early and late. E-LTP requires activation of CaMKII that initiates …

How long-lived memories withstand molecular turnover is a fundamental question.
Aggregates of a prion-like RNA-binding protein, cytoplasmic polyadenylation element …

The polyglutamine expansion of huntingtin (mHTT) causes Huntington disease (HD) and
neurodegeneration, but the mechanisms remain unclear. Here, we found that mHtt promotes …

Posttranscriptional mechanisms provide powerful means to expand the coding power of
genomes. In nervous systems, alternative splicing has emerged as a fundamental …

Animals employ diverse learning rules and synaptic plasticity dynamics to record temporal
and statistical information about the world. However, the molecular mechanisms underlying …

In the last decade, researchers using Drosophila melanogaster have made extraordinary
progress in uncovering the mysteries underlying learning and memory. This progress has …

Memories are thought to be formed in response to transient experiences, in part through
changes in local protein synthesis at synapses. In Drosophila, the amyloidogenic (prion-like) …

Animals consolidate some, but not all, learning experiences into long-term memory. Across
the animal kingdom, sleep has been found to have a beneficial effect on the consolidation of …

LIM kinases are common downstream effectors of several signalization pathways and
function as a signaling node that controls cytoskeleton dynamics through the …