The endothelium, a cellular monolayer lining the blood vessel wall, plays a critical role in
maintaining multiorgan health and homeostasis. Endothelial functions in health include …

Colchicine is an ancient herbal drug derived from Colchicum autumnale. It was first used to
treat familial Mediterranean fever and gout. Based on its unique efficacy as an anti …

The extracellular matrix (ECM) proteoglycan, versican increases along with other ECM
versican binding molecules such as hyaluronan, tumor necrosis factor stimulated gene-6 …

PARPs and tankyrases (TNKS) represent a family of 17 proteins. PARPs and tankyrases
were originally identified as DNA repair factors, nevertheless, recent advances have shed …

Damage‐associated molecular patterns (DAMPs) include endogenous intracellular
molecules released by activated or necrotic cells and extracellular matrix (ECM) molecules …

Metformin is one of the most widely prescribed hypoglycemic drugs and has the potential to
treat many diseases. More and more evidence shows that metformin can regulate the …

Tanshinone IIA (TS), a pharmacologically active component isolated from the rhizome of the
Chinese herb Salvia miltiorrhiza Bunge (Danshen), has been clinically used in Asian …

Lectin-like oxidized LDL (oxLDL) receptor-1 (LOX-1, also known as OLR-1), is a class E
scavenger receptor that mediates the uptake of oxLDL by vascular cells. LOX-1 is involved …

An emerging body of evidence indicates that secreted proteoglycans act as signaling
molecules, in addition to their canonical function in maintaining and regulating the …

Atherosclerosis, the principal cause of cardiovascular death worldwide, is a pathological
disease characterized by fibro-proliferation, chronic inflammation, lipid accumulation, and …