Advances in microfluidics for single red blood cell analysis

GV Grigorev, AV Lebedev, X Wang, X Qian… - Biosensors, 2023 - mdpi.com
The utilizations of microfluidic chips for single RBC (red blood cell) studies have attracted
great interests in recent years to filter, trap, analyze, and release single erythrocytes for …

A review of the relationship between the immune response, inflammation, oxidative stress, and the pathogenesis of sickle cell anaemia

FI Aboderin, T Oduola, GM Davison, OO Oguntibeju - Biomedicines, 2023 - mdpi.com
Sickle cell anaemia (SCD) is a life-threatening haematological disorder which is
predominant in sub-Saharan Africa and is triggered by a genetic mutation of the β-chain …

Classification of red cell dynamics with convolutional and recurrent neural networks: a sickle cell disease case study

M Darrin, A Samudre, M Sahun, S Atwell, C Badens… - Scientific Reports, 2023 - nature.com
The fraction of red blood cells adopting a specific motion under low shear flow is a promising
inexpensive marker for monitoring the clinical status of patients with sickle cell disease. Its …

Changes in the blood viscosity in patients with SARS-CoV-2 infection

HM Al-Kuraishy, AI Al-Gareeb, SM Al-Hamash… - Frontiers in …, 2022 - frontiersin.org
Coronavirus disease 2019 (COVID-19) is caused by a novel virus known as severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2-induced …

Microfluidics approach to the mechanical properties of red blood cell membrane and their effect on blood rheology

C Trejo-Soto, GR Lázaro, I Pagonabarraga… - Membranes, 2022 - mdpi.com
In this article, we describe the general features of red blood cell membranes and their effect
on blood flow and blood rheology. We first present a basic description of membranes and …

Microfluidic systems for blood and blood cell characterization

H Kim, A Zhbanov, S Yang - Biosensors, 2022 - mdpi.com
A laboratory blood test is vital for assessing a patient's health and disease status. Advances
in microfluidic technology have opened the door for on-chip blood analysis. Currently …

Red blood cell adhesion to ICAM-1 is mediated by fibrinogen and is associated with right-to-left shunts in sickle cell disease

E Kucukal, Y Man, E Quinn, N Tewari, R An… - Blood …, 2020 - ashpublications.org
Sickle cell disease (SCD), which afflicts 100 000 Americans, as well as millions worldwide,
is associated with anemia, lifelong morbidity, and early mortality. Abnormal adhesion of …

Effectiveness and safety of fufang danshen dripping pill (cardiotonic pill) on blood viscosity and hemorheological factors for cardiovascular event prevention in patients …

M Wi, Y Kim, CH Kim, S Lee, GS Bae, J Leem, H Chu - Medicina, 2023 - mdpi.com
Background and Objectives: Diabetes can cause various vascular complications. The
Compounded Danshen-Dripping-Pill (CDDP) is widely used in China. This study aimed to …

OcclusionChip: a functional microcapillary occlusion assay complementary to ektacytometry for detection of small-fraction red blood cells with abnormal deformability

Y Man, R An, K Monchamp, Z Sekyonda… - Frontiers in …, 2022 - frontiersin.org
Red blood cell (RBC) deformability is a valuable hemorheological biomarker that can be
used to assess the clinical status and response to therapy of individuals with sickle cell …

Towards access for all: 1st working group report for the global gene therapy initiative (GGTI)

JE Adair, L Androski, L Bayigga, D Bazira, E Brandon… - Gene Therapy, 2023 - nature.com
The gene and cell therapy field saw its first approved treatments in Europe in 2012 and the
United States in 2017 and is projected to be at least a $10 B USD industry by 2025. Despite …