Metabolomics and genomics in natural products research: complementary tools for targeting new chemical entities

LK Caesar, R Montaser, NP Keller… - Natural product reports, 2021 - pubs.rsc.org
Covering: 2010 to 2021 Organisms in nature have evolved into proficient synthetic chemists,
utilizing specialized enzymatic machinery to biosynthesize an inspiring diversity of …

Computational approaches to natural product discovery

MH Medema, MA Fischbach - Nature chemical biology, 2015 - nature.com
Starting with the earliest Streptomyces genome sequences, the promise of natural product
genome mining has been captivating: genomics and bioinformatics would transform …

[HTML][HTML] The secondary metabolite bioinformatics portal: computational tools to facilitate synthetic biology of secondary metabolite production

T Weber, HU Kim - Synthetic and Systems Biotechnology, 2016 - Elsevier
Natural products are among the most important sources of lead molecules for drug
discovery. With the development of affordable whole-genome sequencing technologies and …

Artificial intelligence in microbial natural product drug discovery: current and emerging role

VJ Sahayasheela, MB Lankadasari, VM Dan… - Natural product …, 2022 - pubs.rsc.org
Covering: up to the end of 2022 Microorganisms are exceptional sources of a wide array of
unique natural products and play a significant role in drug discovery. During the golden era …

From genomics to metabolomics, moving toward an integrated strategy for the discovery of fungal secondary metabolites

T Hautbergue, EL Jamin, L Debrauwer, O Puel… - Natural Product …, 2018 - pubs.rsc.org
Fungal secondary metabolites are defined by bioactive properties that ensure adaptation of
the fungus to its environment. Although some of these natural products are promising …

Advances in Genetic Engineering Technology and Its Application in the Industrial Fungus Aspergillus oryzae

FJ Jin, S Hu, BT Wang, L Jin - Frontiers in Microbiology, 2021 - frontiersin.org
The filamentous fungus Aspergillus oryzae is an important strain in the traditional
fermentation and food processing industries and is often used in the production of soy …

Fungal production of kojic acid and its industrial applications

S Chib, VL Jamwal, V Kumar, SG Gandhi… - Applied Microbiology and …, 2023 - Springer
Kojic acid has gained its importance after it was known worldwide that the substance
functions primarily as skin-lightening agent. Kojic acid plays a vital role in skin care products …

Chemodiversity in the genus Aspergillus

JC Frisvad, TO Larsen - Applied Microbiology and Biotechnology, 2015 - Springer
Isolates of Aspergillus species are able to produce a large number of secondary
metabolites. The profiles of biosynthetic families of secondary metabolites are species …

Mycotoxin producers in the Aspergillus genus: An update

J Varga, N Baranyi, M Chandrasekaran… - Acta Biologica …, 2015 - 160.114.156.156
Mycotoxins are secondary metabolites of fungi. Species assigned to the Aspergillus genus
produce a wide range of mycotoxins which can contaminate several agricultural products …

Bioinformatics tools for the identification of gene clusters that biosynthesize specialized metabolites

AK Chavali, SY Rhee - Briefings in bioinformatics, 2018 - academic.oup.com
Specialized metabolites (also called natural products or secondary metabolites) derived
from bacteria, fungi, marine organisms and plants constitute an important source of …