Regulation, functions and transmission of bivalent chromatin during mammalian development
TA Macrae, J Fothergill-Robinson… - … reviews Molecular cell …, 2023 - nature.com
Cells differentiate and progress through development guided by a dynamic chromatin
landscape that mediates gene expression programmes. During development, mammalian …
landscape that mediates gene expression programmes. During development, mammalian …
Advances in epigenetics link genetics to the environment and disease
Epigenetic research has accelerated rapidly in the twenty-first century, generating justified
excitement and hope, but also a degree of hype. Here we review how the field has evolved …
excitement and hope, but also a degree of hype. Here we review how the field has evolved …
Charting cellular identity during human in vitro β-cell differentiation
A Veres, AL Faust, HL Bushnell, EN Engquist… - Nature, 2019 - nature.com
In vitro differentiation of human stem cells can produce pancreatic β-cells; the loss of this
insulin-secreting cell type underlies type 1 diabetes. Here, as a step towards understanding …
insulin-secreting cell type underlies type 1 diabetes. Here, as a step towards understanding …
Context-specific Polycomb mechanisms in development
JJ Kim, RE Kingston - Nature Reviews Genetics, 2022 - nature.com
Polycomb group (PcG) proteins are crucial chromatin regulators that maintain repression of
lineage-inappropriate genes and are therefore required for stable cell fate. Recent advances …
lineage-inappropriate genes and are therefore required for stable cell fate. Recent advances …
[HTML][HTML] Histone H3. 3 K27M accelerates spontaneous brainstem glioma and drives restricted changes in bivalent gene expression
Diffuse intrinsic pontine gliomas (DIPGs) are incurable childhood brainstem tumors with
frequent histone H3 K27M mutations and recurrent alterations in PDGFRA and TP53. We …
frequent histone H3 K27M mutations and recurrent alterations in PDGFRA and TP53. We …
PRC2 is high maintenance
As the process that silences gene expression ensues during development, the stage is set
for the activity of Polycomb-repressive complex 2 (PRC2) to maintain these repressed gene …
for the activity of Polycomb-repressive complex 2 (PRC2) to maintain these repressed gene …
[HTML][HTML] Alterations in beta cell identity in type 1 and type 2 diabetes
Abstract Purpose of Review To discuss the current understanding of “β cell identity” and
factors underlying altered identity of pancreatic β cells in diabetes, especially in humans …
factors underlying altered identity of pancreatic β cells in diabetes, especially in humans …
Leader β-cells coordinate Ca2+ dynamics across pancreatic islets in vivo
Pancreatic β-cells form highly connected networks within isolated islets. Whether this
behaviour pertains to the situation in vivo, after innervation and during continuous perfusion …
behaviour pertains to the situation in vivo, after innervation and during continuous perfusion …
[HTML][HTML] Epigenetic dosage identifies two major and functionally distinct β cell subtypes
The mechanisms that specify and stabilize cell subtypes remain poorly understood. Here,
we identify two major subtypes of pancreatic β cells based on histone mark heterogeneity (β …
we identify two major subtypes of pancreatic β cells based on histone mark heterogeneity (β …
[HTML][HTML] Single-cell transcriptomics of human islet ontogeny defines the molecular basis of β-cell dedifferentiation in T2D
Objective Dedifferentiation of pancreatic β-cells may reduce islet function in type 2 diabetes
(T2D). However, the prevalence, plasticity and functional consequences of this cellular state …
(T2D). However, the prevalence, plasticity and functional consequences of this cellular state …