In mammals, phosphate balance is maintained by influx and efflux via the intestines,
kidneys, bone, and soft tissue, which involves multiple sodium/phosphate (Na+/Pi) …

Renal proximal tubular reabsorption of Pi is a key element in overall Pi homeostasis, and it
involves a secondary active Pi transport mechanism. Among the molecularly identified …

Npt2 encodes a renal-specific, brush-border membrane Na+-phosphate (Pi) cotransporter
that is expressed in the proximal tubule where the bulk of filtered Pi is reabsorbed. Mice …

The Caenorhabditis elegans gene eat-4 affects multiple glutamatergic neurotransmission
pathways. We find that eat-4 encodes a protein similar in sequence to a mammalian brain …

The type IIa Na+-dependent inorganic phosphate (Na/P i) cotransporter is localized in the
apical membrane of proximal tubular cells and is regulated by an endocytotic pathway …

▪ Abstract The physiological tuning and pathophysiological alterations of renal proximal
reabsorption of inorganic phosphate can be ascribed to the net amount of the Na/Pi …

PDZK1: I. A major scaffolder in brush borders of proximal tubular cells. Background In
proximal tubular cells, PDZK1 (NaPi-Cap1) has been implicated in apical expression of the …

The present study was undertaken to define the mechanisms governing the regulation of the
novel renal brush-border membrane (BBM) Na-phosphate (Pi) cotransporter designated …

In vertebrates, the level of inorganic phosphate (Pi) is tightly balanced both inside the cell
and in the whole organism. A number of different Na+-dependent Pi cotransport systems …

The Arabidopsis accelerated cell death 6-1 (acd6-1) mutant shows constitutive defense, cell
death, and extreme dwarf phenotypes. In a screen for acd6-1 suppressors, we identified a …