[HTML][HTML] Towards a comprehensive characterisation of the human internal chemical exposome: Challenges and perspectives
The holistic characterisation of the human internal chemical exposome using high-resolution
mass spectrometry (HRMS) would be a step forward to investigate the environmental …
mass spectrometry (HRMS) would be a step forward to investigate the environmental …
[HTML][HTML] Signatures of mitochondrial dysfunction and impaired fatty acid metabolism in plasma of patients with post-acute sequelae of COVID-19 (PASC)
Exercise intolerance is a major manifestation of post-acute sequelae of severe acute
respiratory syndrome coronavirus infection (PASC, or “long-COVID”). Exercise intolerance in …
respiratory syndrome coronavirus infection (PASC, or “long-COVID”). Exercise intolerance in …
Red blood cells as an organ? How deep omics characterization of the most abundant cell in the human body highlights other systemic metabolic functions beyond …
Introduction: Recently, the classification of two 'novel'organs, the mesentere and interstitium,
was saluted as a scientific breakthrough and disseminated into mainstream media. The …
was saluted as a scientific breakthrough and disseminated into mainstream media. The …
TNF-α–driven inflammation and mitochondrial dysfunction define the platelet hyperreactivity of aging
P Davizon-Castillo, B McMahon… - Blood, The Journal …, 2019 - ashpublications.org
Aging and chronic inflammation are independent risk factors for the development of
atherothrombosis and cardiovascular disease. We hypothesized that aging-associated …
atherothrombosis and cardiovascular disease. We hypothesized that aging-associated …
Mitochondrial ATP fuels ABC transporter-mediated drug efflux in cancer chemoresistance
EL Giddings, DP Champagne, MH Wu, JM Laffin… - Nature …, 2021 - nature.com
Chemotherapy remains the standard of care for most cancers worldwide, however
development of chemoresistance due to the presence of the drug-effluxing ATP binding …
development of chemoresistance due to the presence of the drug-effluxing ATP binding …
High-throughput metabolomics: isocratic and gradient mass spectrometry-based methods
Metabolomics has emerged in the past decade as a highly attractive and impactful
technique for phenotype-level profiling in diverse biological applications. Most recently, the …
technique for phenotype-level profiling in diverse biological applications. Most recently, the …
[HTML][HTML] Mitochondrial-derived vesicles compensate for loss of LC3-mediated mitophagy
Mitochondria are critical metabolic and signaling hubs, and dysregulated mitochondrial
homeostasis is implicated in many diseases. Degradation of damaged mitochondria by …
homeostasis is implicated in many diseases. Degradation of damaged mitochondria by …
Nobiletin fortifies mitochondrial respiration in skeletal muscle to promote healthy aging against metabolic challenge
Circadian disruption aggravates age-related decline and mortality. However, it remains
unclear whether circadian enhancement can retard aging in mammals. We previously …
unclear whether circadian enhancement can retard aging in mammals. We previously …
Genetic polymorphisms and expression of Rhesus blood group RHCE are associated with 2, 3-bisphosphoglycerate in humans at high altitude
Red blood cell (RBC) metabolic reprogramming upon exposure to high altitude contributes
to physiological human adaptations to hypoxia, a multifaceted process critical to health and …
to physiological human adaptations to hypoxia, a multifaceted process critical to health and …
[HTML][HTML] The AML microenvironment catalyzes a stepwise evolution to gilteritinib resistance
SK Joshi, T Nechiporuk, D Bottomly, PD Piehowski… - Cancer cell, 2021 - cell.com
Our study details the stepwise evolution of gilteritinib resistance in FLT3-mutated acute
myeloid leukemia (AML). Early resistance is mediated by the bone marrow …
myeloid leukemia (AML). Early resistance is mediated by the bone marrow …