Structure and mechanism of human ABC transporters

A Alam, KP Locher - Annual Review of Biophysics, 2023 - annualreviews.org
ABC transporters are essential for cellular physiology. Humans have 48 ABC genes
organized into seven distinct families. Of these genes, 44 (in five distinct families) encode for …

[HTML][HTML] Potassium channels as a target for cancer therapy: Current perspectives

L Zúñiga, A Cayo, W González, C Vilos… - OncoTargets and …, 2022 - ncbi.nlm.nih.gov
Potassium (K+) channels are highly regulated membrane proteins that control the potassium
ion flux and respond to different cellular stimuli. These ion channels are grouped into three …

Conformational motions and ligand-binding underlying gating and regulation in IP3R channel

G Fan, MR Baker, LE Terry, V Arige, M Chen… - Nature …, 2022 - nature.com
Abstract Inositol-1, 4, 5-trisphosphate receptors (IP3Rs) are activated by IP3 and Ca2+ and
their gating is regulated by various intracellular messengers that finely tune the channel …

Membrane transporters in drug development and as determinants of precision medicine

A Galetin, KLR Brouwer, D Tweedie… - Nature Reviews Drug …, 2024 - nature.com
The effect of membrane transporters on drug disposition, efficacy and safety is now well
recognized. Since the initial publication from the International Transporter Consortium …

Structural insights into the mechanism of pancreatic KATP channel regulation by nucleotides

M Wang, JX Wu, D Ding, L Chen - Nature communications, 2022 - nature.com
ATP-sensitive potassium channels (KATP) are metabolic sensors that convert the
intracellular ATP/ADP ratio to the excitability of cells. They are involved in many …

Structure of an open KATP channel reveals tandem PIP2 binding sites mediating the Kir6.2 and SUR1 regulatory interface

CM Driggers, YY Kuo, P Zhu, A ElSheikh… - Nature …, 2024 - nature.com
ATP-sensitive potassium (KATP) channels, composed of four pore-lining Kir6. 2 subunits
and four regulatory sulfonylurea receptor 1 (SUR1) subunits, control insulin secretion in …

Subunit composition, molecular environment, and activation of native TRPC channels encoded by their interactomes

A Kollewe, Y Schwarz, K Oleinikov, A Raza, A Haupt… - Neuron, 2022 - cell.com
In the mammalian brain TRPC channels, a family of Ca 2+-permeable cation channels, are
involved in a variety of processes from neuronal growth and synapse formation to transmitter …

KATP channels in focus: Progress toward a structural understanding of ligand regulation

GM Martin, BL Patton, SL Shyng - Current opinion in structural biology, 2023 - Elsevier
K ATP channels are hetero-octameric complexes of four inward rectifying potassium
channels, Kir6. 1 or Kir6. 2, and four sulfonylurea receptors, SUR1, SUR2A, or SUR2B from …

Kir6. 1 and SUR2B in Cantú syndrome

C McClenaghan, CG Nichols - American Journal of …, 2022 - journals.physiology.org
Kir6. 1 and SUR2 are subunits of ATP-sensitive potassium (KATP) channels expressed in a
wide range of tissues. Extensive study has implicated roles of these channel subunits in …

Mechanistic insights on KATP channel regulation from cryo-EM structures

CM Driggers, SL Shyng - Journal of General Physiology, 2022 - rupress.org
Gated by intracellular ATP and ADP, ATP-sensitive potassium (KATP) channels couple cell
energetics with membrane excitability in many cell types, enabling them to control a wide …