Depressive rumination, the default-mode network, and the dark matter of clinical neuroscience

JP Hamilton, M Farmer, P Fogelman, IH Gotlib - Biological psychiatry, 2015 - Elsevier
The intuitive association between self-focused rumination in major depressive disorder
(MDD) and the self-referential operations performed by the brain's default-mode network …

Dynamic functional connectivity: promise, issues, and interpretations

RM Hutchison, T Womelsdorf, EA Allen, PA Bandettini… - Neuroimage, 2013 - Elsevier
The brain must dynamically integrate, coordinate, and respond to internal and external
stimuli across multiple time scales. Non-invasive measurements of brain activity with fMRI …

Large-scale network dysfunction in major depressive disorder: a meta-analysis of resting-state functional connectivity

RH Kaiser, JR Andrews-Hanna, TD Wager… - JAMA …, 2015 - jamanetwork.com
Importance Major depressive disorder (MDD) has been linked to imbalanced
communication among large-scale brain networks, as reflected by abnormal resting-state …

Inflammation is associated with decreased functional connectivity within corticostriatal reward circuitry in depression

JC Felger, Z Li, E Haroon, BJ Woolwine, MY Jung… - Molecular …, 2016 - nature.com
Depression is associated with alterations in corticostriatal reward circuitry. One
pathophysiological pathway that may drive these changes is inflammation. Biomarkers of …

Inflammation effects on motivation and motor activity: role of dopamine

JC Felger, MT Treadway - Neuropsychopharmacology, 2017 - nature.com
Motivational and motor deficits are common in patients with depression and other psychiatric
disorders, and are related to symptoms of anhedonia and motor retardation. These deficits in …

A brain network model for depression: From symptom understanding to disease intervention

BJ Li, K Friston, M Mody, HN Wang… - CNS neuroscience & …, 2018 - Wiley Online Library
Understanding the neural substrates of depression is crucial for diagnosis and treatment.
Here, we review recent studies of functional and effective connectivity in depression, in …

Functional neuroimaging of major depressive disorder: a meta-analysis and new integration of baseline activation and neural response data

JP Hamilton, A Etkin, DJ Furman… - American Journal of …, 2012 - Am Psychiatric Assoc
Objective: Functional neuroimaging investigations of major depressive disorder can
advance both the neural theory and treatment of this debilitating illness. Inconsistency of …

Default-mode and task-positive network activity in major depressive disorder: implications for adaptive and maladaptive rumination

JP Hamilton, DJ Furman, C Chang, ME Thomason… - Biological …, 2011 - Elsevier
BACKGROUND: Major depressive disorder (MDD) has been associated reliably with
ruminative responding; this kind of responding is composed of both maladaptive and …

Accelerated TMS for depression: a systematic review and meta-analysis

AI Sonmez, DD Camsari, AL Nandakumar, JLV Voort… - Psychiatry …, 2019 - Elsevier
Repetitive transcranial magnetic stimulation (TMS) is now widely available for the clinical
treatment of depression, but the associated financial and time burdens are problematic for …

Evidence of a dissociation pattern in resting-state default mode network connectivity in first-episode, treatment-naive major depression patients

X Zhu, X Wang, J Xiao, J Liao, M Zhong, W Wang… - Biological …, 2012 - Elsevier
BACKGROUND: Imaging studies have shown that major depressive disorder (MDD) is
associated with altered activity patterns of the default mode network (DMN). However, the …