Single-cell atlases promise to provide a 'missing link'between genes, diseases and
therapies. By identifying the specific cell types, states, programs and contexts where disease …

Understanding tissue macrophage biology has become challenging in recent years due the
ever-increasing complexity in macrophage-subset identification and functional …

Immune-related adverse events, particularly severe toxicities such as myocarditis, are major
challenges to the utility of immune checkpoint inhibitors (ICIs) in anticancer therapy. The …

Beyond their well-known functions in the acute phases of the immune response, neutrophils
play important roles in the various phases of tumor initiation and progression, through the …

Autoimmunity refers to the phenomenon that the body's immune system produces antibodies
or sensitized lymphocytes to its own tissues to cause an immune response. Immune …

Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in
children is generally milder than in adults, but a proportion of cases result in …

Abstract Purpose of Review Myocarditis is a disease caused by inflammation of the heart
that can progress to dilated cardiomyopathy, heart failure, and eventually death in many …

Exploring the immune mechanism of coxsackievirus B3 (CVB3)-induced myocarditis may
provide a promising therapeutic strategy. Here, we investigated the regulatory role of …

Heart failure is a global problem with high hospitalization and mortality rates. Inflammation
and immune dysfunction are involved in this disease. Owing to their unique function …

Cardiac arrhythmias are a major cause of death and disability. A large number of
experimental cell and animal models have been developed to study arrhythmogenic …