Pulmonary hypertension (PH) encompasses a syndrome of diseases that are characterized
by elevated pulmonary artery pressure and pulmonary vascular remodeling and that …

Airway nerves represent a mechanistically and therapeutically important aspect that requires
better highlighting in the context of diseases such as asthma. Altered structure and function …

PURPOSE Women have more adverse events (AEs) from chemotherapy than men, but few
studies have investigated sex differences in immune or targeted therapies. We examined …

The number of COVID-19 cases appears to be comparable between men and women, but
the severity of disease and death is two times greater for men than for women (1, 2). History …

Sex differences in the anatomy and physiology of the respiratory system have been widely
reported. These intrinsic sex differences have also been shown to modulate the …

Rationale: Cystic fibrosis (CF) is a life-shortening, multisystem hereditary disease caused by
abnormal chloride transport. CF lung disease is driven by innate immune dysfunction and …

Inflammation is a characteristic marker in numerous lung disorders. Several immune cells,
such as macrophages, dendritic cells, eosinophils, as well as T and B lymphocytes …

Pulmonary arterial hypertension (PAH) is a complex disease of multifactorial origin. While
registries have demonstrated that women are more susceptible to the disease, females with …

There are marked sex differences in asthma prevalence and severity. Sex hormones play a
central role in these sex biases and directly interact with multiple key cells involved in the …

Background Morbidity and mortality associated with childhood asthma are driven
disproportionately by children with severe asthma. However, it is not known from …