Prostanoid receptor antagonists: development strategies and therapeutic applications

RL Jones, MA Giembycz… - British journal of …, 2009 - Wiley Online Library
Identification of the primary products of cyclo‐oxygenase (COX)/prostaglandin synthase (s),
which occurred between 1958 and 1976, was followed by a classification system for …

[HTML][HTML] Oxytocin receptor antagonists, atosiban and nolasiban, inhibit prostaglandin F2α-induced contractions and inflammatory responses in human myometrium

SH Kim, L Riaposova, H Ahmed, O Pohl, A Chollet… - Scientific Reports, 2019 - nature.com
Oxytocin receptor antagonists (OTR-A) have been developed as tocolytics for the
management of preterm labour due to the significant role of oxytocin (OT) in the onset of …

Advances in the role of oxytocin receptors in human parturition

SH Kim, PR Bennett, V Terzidou - Molecular and cellular endocrinology, 2017 - Elsevier
Oxytocin (OT) is a neurohypophysial hormone which has been found to play a central role in
the regulation of human parturition. The most established role of oxytocin/oxytocin receptor …

Cooperative effects of sequential PGF and IL-1β on IL-6 and COX-2 expression in human myometrial cells

KB Leimert, BSE Verstraeten, A Messer… - Biology of …, 2019 - academic.oup.com
The change from the state of pregnancy to the state of parturition, which we call uterine
transitioning, requires the actions of inflammatory mediators and results in an activated …

Oxytocin and vasopressin signalling and myometrial contraction

S Arrowsmith - Current opinion in physiology, 2020 - Elsevier
Oxytocin and vasopressin are potent stimulants of uterine contractions. The importance of
these hormones, particularly oxytocin, in pregnancy and labour, has been extensively …

Prostaglandin FP receptor antagonists: discovery, pharmacological characterization and therapeutic utility

NA Sharif, PG Klimko - British journal of pharmacology, 2019 - Wiley Online Library
In contrast to the availability of potent and selective antagonists of several prostaglandin
receptor types (including DP1, DP2, EP and TP receptors), there has been a paucity of well …

PG F Receptor: A Promising Therapeutic Target for Cardiovascular Disease

J Zhang, Y Gong, Y Yu - Frontiers in pharmacology, 2010 - frontiersin.org
Prostaglandins (PGs), a group of key lipid mediators, are involved in numerous
physiological and pathological processes including inflammation and cardiovascular …

A first-in-human study of PDC31 (prostaglandin F receptor inhibitor) in primary dysmenorrhea

B Böttcher, RM Laterza, L Wildt, RJ Seufert… - Human …, 2014 - academic.oup.com
STUDY QUESTION What is the safe and pharmacodynamically active dose range for
PDC31 (prostaglandin F2α receptor inhibitor) in patients with primary dysmenorrhea (PD) …

Comparative efficacy of uterotonic agents: in vitro contractions in isolated myometrial strips of labouring and non-labouring women

M Balki, M Erik-Soussi… - Canadian Journal of …, 2014 - search.proquest.com
Purpose To compare the in vitro contractile responses to oxytocin, ergonovine,
prostaglandin F 2 alpha (PGF 2 α), and misoprostol in isolated myometrium from non …

[引用][C] International Union of Basic and Clinical Pharmacology. LXXXIII: classification of prostanoid receptors, updating 15 years of progress

DF Woodward, RL Jones, S Narumiya - Pharmacological reviews, 2011 - ASPET