Antibiotic resistance diagnosis in ESKAPE pathogens—a review on proteomic perspective

S Kalpana, WY Lin, YC Wang, Y Fu, A Lakshmi… - Diagnostics, 2023 - mdpi.com
Antibiotic resistance has emerged as an imminent pandemic. Rapid diagnostic assays
distinguish bacterial infections from other diseases and aid antimicrobial stewardship …

MALDI-TOF mass spectrometry technology as a tool for the rapid diagnosis of antimicrobial resistance in bacteria

EJ Yoon, SH Jeong - Antibiotics, 2021 - mdpi.com
Species identification by using matrix-assisted laser desorption/ionization time-of-flight mass
spectrometry (MALDI-TOF MS) is a routine diagnostic process for infectious diseases in …

Direct antimicrobial resistance prediction from clinical MALDI-TOF mass spectra using machine learning

C Weis, A Cuénod, B Rieck, O Dubuis, S Graf… - Nature Medicine, 2022 - nature.com
Early use of effective antimicrobial treatments is critical for the outcome of infections and the
prevention of treatment resistance. Antimicrobial resistance testing enables the selection of …

Rapid identification of methicillin-resistant Staphylococcus aureus using MALDI-TOF MS and machine learning from over 20,000 clinical isolates

J Yu, N Tien, YC Liu, DY Cho, JW Chen… - Microbiology …, 2022 - Am Soc Microbiol
Rapidly identifying methicillin-resistant Staphylococcus aureus (MRSA) with high integration
in the current workflow is critical in clinical practices. We proposed a matrix-assisted laser …

Rapid identification of carbapenem-resistant Klebsiella pneumoniae based on matrix-assisted laser desorption ionization time-of-flight mass spectrometry and an …

YM Zhang, MF Tsao, CY Chang, KT Lin… - Journal of Biomedical …, 2023 - Springer
Abstract Background Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a clinically
critical pathogen that causes severe infection. Due to improper antibiotic administration, the …

Efficiently Predicting Vancomycin Resistance of Enterococcus Faecium From MALDI-TOF MS Spectra Using a Deep Learning-Based Approach

HY Wang, TT Hsieh, CR Chung, HC Chang… - Frontiers in …, 2022 - frontiersin.org
Matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry
(MS) has recently become a useful analytical approach for microbial identification. The …

Identifying anti-coronavirus peptides by incorporating different negative datasets and imbalanced learning strategies

Y Pang, Z Wang, JH Jhong, TY Lee - Briefings in bioinformatics, 2021 - academic.oup.com
As the current worldwide outbreaks of the SARS-CoV-2, it is urgently needed to develop
effective therapeutic agents for inhibiting the pathogens or treating the related diseases …

[HTML][HTML] Energy efficiency of inference algorithms for clinical laboratory data sets: Green artificial intelligence study

JR Yu, CH Chen, TW Huang, JJ Lu, CR Chung… - Journal of Medical …, 2022 - jmir.org
Background The use of artificial intelligence (AI) in the medical domain has attracted
considerable research interest. Inference applications in the medical domain require energy …

Cas12a/Guide RNA-based platforms for rapidly and accurately identifying Staphylococcus aureus and methicillin-resistant S. aureus

X Cao, Y Chang, C Tao, S Chen, Q Lin… - Microbiology …, 2023 - Am Soc Microbiol
In order to ensure the prevention and control of methicillin-resistant Staphylococcus aureus
(MRSA) infection, rapid and accurate detection of pathogens and their resistance …

Using Protein Fingerprinting for Identifying and Discriminating Methicillin Resistant Staphylococcus aureus Isolates from Inpatient and Outpatient Clinics

A Elbehiry, E Marzouk, I Moussa, S Anagreyyah… - Diagnostics, 2023 - mdpi.com
In hospitals and other clinical settings, Methicillin-resistant Staphylococcus aureus (MRSA)
is a particularly dangerous pathogen that can cause serious or even fatal infections. Thus …