Glycosylation characteristics of colorectal cancer
S Holst, M Wuhrer, Y Rombouts - Advances in cancer research, 2015 - Elsevier
Glycans on proteins and lipids are known to alter with malignant transformation. The study of
these may contribute to the discovery of biomarkers and treatment targets as well as …
these may contribute to the discovery of biomarkers and treatment targets as well as …
Glycolipids and lectins in endocytic uptake processes
A host of endocytic processes has been described at the plasma membrane of eukaryotic
cells. Their categorization has most commonly referenced cytosolic machinery, of which the …
cells. Their categorization has most commonly referenced cytosolic machinery, of which the …
Deciphering the importance of glycosphingolipids on cellular and molecular mechanisms associated with epithelial-to-mesenchymal transition in cancer
Every living cell is covered with a dense and complex layer of glycans on the cell surface,
which have important functions in the interaction between cells and their environment …
which have important functions in the interaction between cells and their environment …
High diversity of glycosphingolipid glycans of colorectal cancer cell lines reflects the cellular differentiation phenotype
Colorectal cancer (CRC)–associated changes of protein glycosylation have been widely
studied. In contrast, the expression of glycosphingolipid (GSL) patterns in CRC has, hitherto …
studied. In contrast, the expression of glycosphingolipid (GSL) patterns in CRC has, hitherto …
Therapeutic uses of bacterial subunit toxins
C Lingwood - Toxins, 2021 - mdpi.com
The B subunit pentamer verotoxin (VT aka Shiga toxin-Stx) binding to its cellular
glycosphingolipid (GSL) receptor, globotriaosyl ceramide (Gb3) mediates internalization and …
glycosphingolipid (GSL) receptor, globotriaosyl ceramide (Gb3) mediates internalization and …
Protection against Shiga toxins
S Kavaliauskiene, AB Dyve Lingelem, T Skotland… - Toxins, 2017 - mdpi.com
Shiga toxins consist of an A-moiety and five B-moieties able to bind the neutral
glycosphingolipid globotriaosylceramide (Gb3) on the cell surface. To intoxicate cells …
glycosphingolipid globotriaosylceramide (Gb3) on the cell surface. To intoxicate cells …
Investigations on aberrant glycosylation of glycosphingolipids in colorectal cancer tissues using liquid chromatography and matrix-assisted laser desorption time-of …
S Holst, K Stavenhagen, CIA Balog… - Molecular & Cellular …, 2013 - ASBMB
Cancer is a leading cause of death and alterations of glycosylation are characteristic
features of malignant cells. Colorectal cancer is one of the most common cancers and its …
features of malignant cells. Colorectal cancer is one of the most common cancers and its …
The glycosphingolipid P1 is an ovarian cancer-associated carbohydrate antigen involved in migration
F Jacob, M Anugraham, T Pochechueva… - British journal of …, 2014 - nature.com
Background: The level of plasma-derived naturally circulating anti-glycan antibodies (AGA)
to P 1 trisaccharide has previously been shown to significantly discriminate between ovarian …
to P 1 trisaccharide has previously been shown to significantly discriminate between ovarian …
Expression of GBGT1 is epigenetically regulated by DNA methylation in ovarian cancer cells
Background The GBGT1 gene encodes the globoside alpha-1, 3-N-
acetylgalactosaminyltransferase 1. This enzyme catalyzes the last step in the multi-step …
acetylgalactosaminyltransferase 1. This enzyme catalyzes the last step in the multi-step …
Cell density-induced changes in lipid composition and intracellular trafficking
S Kavaliauskiene, CM Nymark, J Bergan… - Cellular and molecular …, 2014 - Springer
Cell density is one of the extrinsic factors to which cells adapt their physiology when grown
in culture. However, little is known about the molecular changes which occur during cell …
in culture. However, little is known about the molecular changes which occur during cell …