Autoreactive B cells and interferons are central players in systemic lupus erythematosus
(SLE) pathogenesis. The partial success of drugs targeting these pathways, however …

Adaptive immune responses mediated by T cells and B cells are crucial for protective
immunity against pathogens and tumors. Differentiation and function of immune cells require …

Tumor-infiltrating T cells offer a promising avenue for cancer treatment, yet their states
remain to be fully characterized. Here we present a single-cell atlas of T cells from 308,048 …

The complement system is a recognized pillar of host defence against infection and noxious
self-derived antigens. Complement is traditionally known as a serum-effective system …

Research elucidating the pathogenesis of systemic lupus erythematosus (SLE) has defined
two critical families of mediators, type I interferon (IFN-I) and autoantibodies targeting nucleic …

Reports of widespread thromboses and disseminated intravascular coagulation (DIC) in
patients with coronavirus disease 19 (COVID-19) have been rapidly increasing in number …

The immunopathogenesis of rheumatoid arthritis (RA) spans decades, beginning with the
production of autoantibodies against post-translationally modified proteins (checkpoint 1) …

A key unknown of the functional space in tumor immunity is whether CD4 T cells depend on
intratumoral MHCII cancer antigen recognition. MHCII-expressing, antigen-presenting …

Approximately 5% of the world-wide population is affected by autoimmune diseases.
Overall, autoimmune diseases are still difficult to treat, impose a high burden on patients …

The recognition of microbial or danger-associated molecular patterns by complement
proteins initiates a cascade of events that culminates in the activation of surface complement …