Dementia is a leading cause of disability and death worldwide. At present there is no
disease modifying treatment for any of the most common types of dementia such as …

Cerebrospinal fluid analyses and neuroimaging can identify the underlying pathophysiology
at the earliest stage of some neurodegenerative disorders, but do not have the scalability …

A single dose of psilocybin, a psychedelic and serotonin 2A receptor (5-HT2AR) agonist,
may be associated with antidepressant effects. The mechanism behind its antidepressive …

Synapses are the site for brain communication where information is transmitted between
neurons and stored for memory formation. Synaptic degeneration is a global and early …

Parkinson's disease (PD) is a neurodegenerative disorder that affects millions of people
worldwide. Two hallmarks of PD are the accumulation of alpha‐synuclein and the loss of …

Current advances in plasma and cerebrospinal fluid biomarker... : Current Opinion in Neurology
Current advances in plasma and cerebrospinal fluid biomarkers in Alzheimer's disease …

Alzheimer's Disease (AD), the leading cause of senile dementia, is a progressive
neurodegenerative disorder affecting millions of people worldwide and exerting tremendous …

Objective Synaptic loss is an early feature of neurodegenerative disease models, and is
severe in post mortem clinical studies, including frontotemporal dementia. Positron emission …

Background The mechanism of synaptic loss in Alzheimer's disease is poorly understood
and may be associated with tau pathology. In this combined positron emission tomography …

Background It has been hypothesized that the pathology of Parkinson's disease (PD)
primarily affects presynaptic terminals and spreads trans‐synaptically. Objectives The main …