Copper is essential for life processes like energy metabolism, reactive oxygen species
detoxification, iron uptake, and signaling in eukaryotic organisms. Mitochondria gather …

In the past decade, evidence for the numerous roles of copper (Cu) in mammalian
physiology has grown exponentially. The discoveries of Cu involvement in cell signaling …

As an essential nutrient, copper's redox properties are both beneficial and toxic to cells.
Therefore, leveraging the characteristics of copper-dependent diseases or using copper …

Mitochondria serve as sites for energy production and are essential for regulating various
forms of cell death induced by metal metabolism, targeted anticancer drugs, radiotherapy …

Cholestatic chronic liver disease is characterized by developing sarcopenia and elevated
serum levels of bile acids. Sarcopenia is a skeletal muscle disorder with the hallmarks of …

Background Skeletal muscle is sensitive to bile acids (BA) because it expresses the TGR5
receptor for BA. Cholic (CA) and deoxycholic (DCA) acids induce a sarcopenia-like …

Trace metal elements are of vital importance for fundamental biological processes. They
function in various metabolic pathways after the long evolution of living organisms. Glucose …

Mitochondria, the major organelles that produce energy for cell survival and function,
dynamically change their morphology via fusion and fission, a process called mitochondrial …

As an essential trace metal, copper (Cu) regulation, distribution and detoxification among
different cellular organelles remain much unknown. In the current study, bioimaging tool was …

A series of copper (II) complexes with the formula [Cu2+ Hy (x) Car%] varying the molecular
weight (MW) of Hyaluronic acid (Hy, x= 200 or 700 kDa) conjugated with carnosine (Car) …