This update, written by authors designated by multiple pediatric endocrinology societies
(see List of Participating Societies) from around the globe, concisely addresses topics …

Central precocious puberty (CPP) results from early activation of the hypothalamic-pituitary-
gonadal (HPG) axis and follows the same sequence as normal puberty. While many factors …

Precocious puberty is defined as the appearance of secondary sex characteristics before 8
years of age in girls and before 9 years of age in boys. Central precocious puberty (CPP) is …

Long-acting analogs of GnRH (GnRHas) have been the gold-standard treatment of central
precocious puberty (CPP) worldwide and have an enviable track record of safety and …

Central precocious puberty (CPP) refers to early activation of the hypothalamic–pituitary–
gonadal (HPG) axis and is manifested by breast development in girls or testicular …

Objective To investigate the long‐term efficacy and safety of gonadotropin‐releasing
hormone analog (GnRHa) treatment in children with idiopathic central precocious puberty …

The use of gonadotropin-releasing hormone analogs (GnRHa) for the treatment of central
precocious puberty (CPP), especially in girls, has increased rapidly in recent years. In the …

Precocious puberty (PP) in girls refers to secondary sexual development occurring earlier
than the lower end of normal for the onset of puberty. It might be the presenting feature of a …

Problem Precocious puberty (PP) is an illness that appears when puberty, begins some
years earlier than usual, provoking inferences in preadolescents and adolescents and their …

Central precocious puberty (CPP) classically refers to premature activation of the
hypothalamic–pituitary–gonadal axis with onset of sexual development before the age of 8 …