Atherosclerosis is a chronic vascular inflammatory disease associated to oxidative stress
and endothelial dysfunction. Oxidation of low‐density lipoprotein (LDL) cholesterol is one of …

Oxidative stress and inflammation interact in the development of diabetic atherosclerosis.
Intracellular hyperglycemia promotes production of mitochondrial reactive oxygen species …

Senescence compromises the essential role that the endothelium plays in maintaining
vascular homeostasis, so promoting endothelial dysfunction and the development of age …

Nitric oxide (NO) is a small free radical with critical signaling roles in physiology and
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …

This review takes an inclusive approach to microvascular dysfunction in diabetes mellitus
and cardiometabolic disease. In virtually every organ, dynamic interactions between the …

The cardiovascular complications contribute to a majority of diabetes associated morbidity
and mortality, accounting for 44% of death in those patients with type 1 diabetes mellitus …

Background: Type 2 diabetes mellitus (T2DM) has emerged as a pandemic. It has different
complications, both microvascular and macrovascular. Objective: The purpose of this review …

Endothelial cells (ECs) are more than inert blood vessel lining material. Instead, they are
active players in the formation of new blood vessels (angiogenesis) both in health and (life …

Nitric oxide (NO) represents a potential wound therapeutic agent due to its ability to regulate
inflammation and eradicate bacterial infections. Two broad strategies exist to utilize NO for …

Diabetic macroangiopathy, atherosclerosis secondary to diabetes mellitus (DM), causes
cerebro-cardiovascular diseases, which are major causes of death in patients with DM and …