Neurodegeneration in diabetic retinopathy: does it really matter?

R Simó, AW Stitt, TW Gardner - Diabetologia, 2018 - Springer
The concept of diabetic retinopathy as a microvascular disease has evolved, in that it is now
considered a more complex diabetic complication in which neurodegeneration plays a …

The evolving treatment of diabetic retinopathy

SE Mansour, DJ Browning, K Wong… - Clinical …, 2020 - Taylor & Francis
Purpose To review the current therapeutic options for the management of diabetic
retinopathy (DR) and diabetic macular edema (DME) and examine the evidence for …

Neurodegeneration in the diabetic eye: new insights and therapeutic perspectives

R Simo, C Hernández - Trends in Endocrinology & Metabolism, 2014 - cell.com
Diabetic retinopathy (DR), one of the leading causes of preventable blindness, has been
considered a microcirculatory disease of the retina. However, there is emerging evidence to …

Early detection of diabetic retinopathy

H Safi, S Safi, A Hafezi-Moghadam… - Survey of ophthalmology, 2018 - Elsevier
Diabetic retinopathy (DR) is a primary cause of visual impairment worldwide. Diabetes
mellitus may be associated with ophthalmoscopically nonvisible neurovascular damage that …

The significance of vascular and neural apoptosis to the pathology of diabetic retinopathy

AJ Barber, TW Gardner… - … ophthalmology & visual …, 2011 - iovs.arvojournals.org
The most striking features of diabetic retinopathy are the vascular abnormalities that are
apparent by fundus examination. There is also strong evidence that diabetes causes …

Novel approaches for treating diabetic retinopathy based on recent pathogenic evidence

R Simo, C Hernandez - Progress in retinal and eye research, 2015 - Elsevier
Diabetic retinopathy remains as a leading cause of blindness in developed countries.
Current treatments target late stages of DR when vision has already been significantly …

Decreased retinal ganglion cell layer thickness in patients with type 1 diabetes

HW Van Dijk, FD Verbraak, PHB Kok… - … & visual science, 2010 - iovs.arvojournals.org
Purpose.: To determine which retinal layers are most affected by diabetes and contribute to
thinning of the inner retina and to investigate the relationship between retinal layer thickness …

[HTML][HTML] Diabetes and retinal vascular dysfunction

ES Shin, CM Sorenson, N Sheibani - Journal of ophthalmic & …, 2014 - ncbi.nlm.nih.gov
Diabetes predominantly affects the microvascular circulation of the retina resulting in a
range of structural changes unique to this tissue. These changes ultimately lead to altered …

[HTML][HTML] Diabetic retinopathy is a neurodegenerative disorder

SK Lynch, MD Abràmoff - Vision research, 2017 - Elsevier
Since 1875, controversy has ensued over whether ocular diabetic complications are
primarily vasculopathic or neuropathic in nature. Here, we discuss the historical context by …

Human vitreous in proliferative diabetic retinopathy: characterization and translational implications

IM Nawaz, S Rezzola, A Cancarini, A Russo… - Progress in retinal and …, 2019 - Elsevier
Diabetic retinopathy (DR) is one of the leading causes of visual impairment in the working-
age population. DR is a progressive eye disease caused by long-term accumulation of …