ABSTRACT G-quadruplexes are higher-order DNA and RNA structures formed from G-rich
sequences that are built around tetrads of hydrogen-bonded guanine bases. Potential …

The initiation of V (D) J recombination by the recombination activating gene 1 (RAG1) and
RAG2 proteins is carefully orchestrated to ensure that antigen receptor gene assembly …

This review summarizes recent evidence concerning molecular changes in the commonest
type of lymphoma, diffuse large-B-cell lymphoma. Detailed studies have revealed three …

Chromosomal translocations involving the immunoglobulin loci are a hallmark of many types
of B-cell lymphoma. Other factors, however, also have important roles in the pathogenesis of …

The realization, now more than half a century ago, that B cells can generate antibodies to an
astounding variety of chemical structures sparked intense interest in the “generation of …

The understanding of the molecular pathogenesis of non-Hodgkin's lymphomas (NHL) has
significantly improved in recent years. Advances in molecular biology and genetics lead to …

Aberrant fusions between heterologous chromosomes are among the most prevalent
cytogenetic abnormalities found in cancer cells. Oncogenic chromosomal translocations …

Transcription in mammalian nuclei is highly compartmentalized in RNA polymerase II-
enriched nuclear foci known as transcription factories. Genes in cis and trans can share the …

Abstract V (D) J recombination is the process by which the variable region exons encoding
the antigen recognition sites of receptors expressed on B and T lymphocytes are generated …

The critical initial step in V (D) J recombination, binding of RAG1 and RAG2 to
recombination signal sequences flanking antigen receptor V, D, and J gene segments, has …