Columns packed with sub-2μm totally porous and sub-3μm core–shell particles are very
widespread nowadays to conduct fast and efficient separations. In order to carry out really …

The first part of the review contrasts the main drawbacks of silica-based packings such as
their relative thermal and chemical instability with excellent stability of metal oxides. The …

At present, in high-performance liquid chromatography (HPLC) for the majority of analyses,
reversed-phase liquid chromatography (RPLC) is the separation mode of choice. Faster …

In this part of the review authors discuss methods used for modification of metal oxide
surfaces. On the basis of literature data it is shown, that silanization of the surfaces do not …

Product specifications, regulatory constraints, and tight production schedules impose
considerable pressures on separation scientists in industry. The first edition of HPLC …

Temperature, as a powerful variable in conventional LC is discussed from a fundamental
point of view and illustrated with applications from the author's laboratory. Emphasis is given …

In the last few years, there have been a lot of advances in the field of liquid chromatography
(LC) and supercritical fluid chromatography (SFC). The intent of this review is to summarize …

This review has been written in the context of critically evaluating the potential of high
temperature liquid chromatography for the improvement of separation efficiency. The focus …

High-temperature liquid chromatography (HTLC), with a superheated water mobile phase,
has been shown to be a feasible replacement for medium-polarity acetonitrile–water …

To define starting conditions for the development of methods to separate impurities from the
active substance and from each other in drugs with an unknown impurity profile, the parallel …