Shattering barriers toward clinically meaningful MSC therapies
More than 1050 clinical trials are registered at FDA. gov that explore multipotent
mesenchymal stromal cells (MSCs) for nearly every clinical application imaginable …
mesenchymal stromal cells (MSCs) for nearly every clinical application imaginable …
Functional heterogeneity of mesenchymal stem cells from natural niches to culture conditions: implications for further clinical uses
LA Costa, N Eiro, M Fraile, LO Gonzalez, J Saá… - Cellular and Molecular …, 2021 - Springer
Mesenchymal stem cells (MSC) are present in all organs and tissues. Several studies have
shown the therapeutic potential effect of MSC or their derived products. However, the …
shown the therapeutic potential effect of MSC or their derived products. However, the …
Mesenchymal stem cell perspective: cell biology to clinical progress
MF Pittenger, DE Discher, BM Péault… - NPJ Regenerative …, 2019 - nature.com
The terms MSC and MSCs have become the preferred acronym to describe a cell and a cell
population of multipotential stem/progenitor cells commonly referred to as mesenchymal …
population of multipotential stem/progenitor cells commonly referred to as mesenchymal …
Biological functions of mesenchymal stem cells and clinical implications
Mesenchymal stem cells (MSCs) are isolated from multiple biological tissues—adult bone
marrow and adipose tissues and neonatal tissues such as umbilical cord and placenta. In …
marrow and adipose tissues and neonatal tissues such as umbilical cord and placenta. In …
PI3K/Akt and HIF‑1 signaling pathway in hypoxia‑ischemia
Z Zhang, L Yao, J Yang, Z Wang… - Molecular medicine …, 2018 - spandidos-publications.com
Abstract Hypoxia‑ischemia (H‑I) is frequently observed in perinatal asphyxia and other
diseases. It can lead to serious cardiac injury, cerebral damage, neurological disability and …
diseases. It can lead to serious cardiac injury, cerebral damage, neurological disability and …
Potential pre-activation strategies for improving therapeutic efficacy of mesenchymal stem cells: current status and future prospects
M Li, Y Jiang, Q Hou, Y Zhao, L Zhong, X Fu - Stem cell research & …, 2022 - Springer
Mesenchymal stem cell (MSC)-based therapy has been considered as a promising
approach targeting a variety of intractable diseases due to remarkable multiple effect of …
approach targeting a variety of intractable diseases due to remarkable multiple effect of …
Mesenchymal stem cell therapy for the treatment of inflammatory diseases: challenges, opportunities, and future perspectives
Mesenchymal stem cells (MSCs) are promising alternative agents for the treatment of
inflammatory disorders due to their immunomodulatory functions, and several clinical trials …
inflammatory disorders due to their immunomodulatory functions, and several clinical trials …
Stem cell therapy in heart diseases–cell types, mechanisms and improvement strategies
P Müller, H Lemcke, R David - Cellular Physiology and Biochemistry, 2018 - karger.com
A large number of clinical trials have shown stem cell therapy to be a promising therapeutic
approach for the treatment of cardiovascular diseases. Since the first transplantation into …
approach for the treatment of cardiovascular diseases. Since the first transplantation into …
Extracellular vesicles derived from human bone marrow mesenchymal stem cells promote angiogenesis in a rat myocardial infarction model
S Bian, L Zhang, L Duan, X Wang, Y Min… - Journal of molecular …, 2014 - Springer
Mesenchymal stem cells (MSCs) have been increasingly tested experimentally and clinically
for cardiac repair. However, the underlying mechanisms remain controversial due to the …
for cardiac repair. However, the underlying mechanisms remain controversial due to the …
The therapeutic potential of the mesenchymal stem cell secretome in ischaemic stroke
CJ Cunningham, E Redondo-Castro… - Journal of Cerebral …, 2018 - journals.sagepub.com
Mesenchymal stem cells (MSCs) hold great potential as a regenerative therapy for stroke,
leading to increased repair and functional recovery in animal models of cerebral ischaemia …
leading to increased repair and functional recovery in animal models of cerebral ischaemia …