Alkaloids are an important class of natural products that are widely distributed in nature and
produced by a large variety of organisms. They have a wide spectrum of biological activity …

Alkaloids are a group of approximately 12000 low molecular weight and nitrogenous
secondary metabolites found in 20% of plant species. Their potent biological activity …

Benzylisoquinoline alkaloids, such as the analgesic compounds morphine and codeine, and
the antibacterial agents berberine, palmatine, and magnoflorine, are synthesized from …

Abstract The Pictet–Spengler reaction (PSR) involves the condensation and ring closure
between a β-arylethylamine and a carbonyl compound. The combination of dopamine and …

Norcoclaurine synthase (NCS)(EC 4.2. 1.78) catalyzes the Pictet–Spengler condensation of
dopamine and an aldehyde, forming a substituted (S)‐tetrahydroisoquinoline, a …

The versatility and potential of a norcoclaurine synthase (NCS) from Coptis japonica NCS2
has been investigated, together with the development and application of a novel …

Norcoclaurine synthase (NCS) catalyzes the stereoselective Pictet–Spengler reaction
between dopamine and 4-hydroxyphenylacetaldehyde as the first step of benzylisoquinoline …

Benzylisoquinoline alkaloids (BIAs) are an important family of plant-derived metabolites with
diverse biological activities. Owing to their structural complexity and high stereoselectivity …

Traditional methods of chemical synthesis of alkaloids exhibit various problems such as lack
of enantioselectivity, the use of toxic chemical and intermediates, and multiple numbers of …

Plant-derived alkaloids are an important class of pharmaceuticals. However, they still rely on
phytoextraction to meet their diverse market demands. Since multistep biocatalytic cascades …