5-Ene-4-thiazolidinones–An efficient tool in medicinal chemistry
The presented review is an attempt to summarize a huge volume of data on 5-ene-4-
thiazolidinones being a widely studied class of small molecules used in modern organic and …
thiazolidinones being a widely studied class of small molecules used in modern organic and …
A conceptual review of rhodanine: current applications of antiviral drugs, anticancer and antimicrobial activities
Rhodanines are accepted as advantaged heterocycles in medicinal chemistry as one of the
4-thiazolidinones subtypes. The aim of this paper is to analyze the features of rhodanine and …
4-thiazolidinones subtypes. The aim of this paper is to analyze the features of rhodanine and …
Recent developments with rhodanine as a scaffold for drug discovery
D Kaminskyy, A Kryshchyshyn… - Expert Opinion on Drug …, 2017 - Taylor & Francis
Introduction: Rhodanines, as one of the 4-thiazolidinones subtypes, are recognized as
privileged heterocycles in medicinal chemistry. The main achievements include the …
privileged heterocycles in medicinal chemistry. The main achievements include the …
Rhodanine as a scaffold in drug discovery: a critical review of its biological activities and mechanisms of target modulation
T Tomašić, L Peterlin Mašič - Expert opinion on drug discovery, 2012 - Taylor & Francis
Introduction: Rhodanine-based compounds have been associated with numerous biological
activities. After many years of research in drug discovery, they have gained a reputation as …
activities. After many years of research in drug discovery, they have gained a reputation as …
Synthesis and biological evaluation of purine-pyrazole hybrids incorporating thiazole, thiazolidinone or rhodanine moiety as 15-LOX inhibitors endowed with …
OS Afifi, OG Shaaban, HA Abd El Razik, SEDAS El… - Bioorganic …, 2019 - Elsevier
Novel purine-pyrazole hybrids combining thiazoles, thiazolidinones and rhodanines, were
designed and tested as 15-LOX inhibitors, potential anticancer and antioxidant agents. All …
designed and tested as 15-LOX inhibitors, potential anticancer and antioxidant agents. All …
Synthesis and biological evaluation of novel 2-aralkyl-5-substituted-6-(4′-fluorophenyl)-imidazo [2, 1-b][1, 3, 4] thiadiazole derivatives as potent anticancer agents
Levamisole, the imidazo [2, 1-b] thiazole derivative has been reported as a potential
antitumor agent. In the present study, we synthesized, characterized and evaluated …
antitumor agent. In the present study, we synthesized, characterized and evaluated …
Study of novel anticancer 4-thiazolidinone derivatives
Thiazolidinones are a known class of prospective drug-like molecules, especially in the
design of new anticancer agents. Two of the most prominent subtypes of these compounds …
design of new anticancer agents. Two of the most prominent subtypes of these compounds …
Synthesis, molecular geometry, spectroscopic studies and thermal properties of Co (II) complexes
Co (II) complexes (1‐4) were prepared and characterized by elemental analyses, infrared
spectra, spectral studies, magnetic susceptibility measurements, X‐ray diffraction analysis …
spectra, spectral studies, magnetic susceptibility measurements, X‐ray diffraction analysis …
5-Ene-4-thiazolidinones induce apoptosis in mammalian leukemia cells
J Senkiv, N Finiuk, D Kaminskyy, D Havrylyuk… - European Journal of …, 2016 - Elsevier
The article presents the synthesis of 5-ene-4-thiazolidinone derivatives with pyrazole core
linked by enamine group. The structure and purity of compounds were confirmed by …
linked by enamine group. The structure and purity of compounds were confirmed by …
[HTML][HTML] Synthesis, modeling, and biological studies of new thiazole-pyrazole analogues as anticancer agents
A series of various substituted thiazole-pyrazole hybrids 5, 7, 8, and 9 were synthesized, and
their chemical structures were confirmed by spectral data (infrared, 1 H & 13 C NMR and …
their chemical structures were confirmed by spectral data (infrared, 1 H & 13 C NMR and …