We provide a comprehensive classification of the proteoglycan gene families and respective
protein cores. This updated nomenclature is based on three criteria: Cellular and subcellular …

Extracellular matrix is a highly dynamic macromolecular network. Proteoglycans are major
components of extracellular matrix playing key roles in its structural organization and cell …

Pericytes adhere to the abluminal surface of endothelial tubules and are required for the
formation of stable vascular networks. Defective endothelial cell-pericyte interactions are …

Gliomas are a diverse group of primary central nervous system tumors that affect both
children and adults. Recent studies have revealed a dynamic cross talk that occurs between …

Glioblastoma, a malignant brain cancer, is characterized by abnormal activation of receptor
tyrosine kinase signalling pathways and a poor prognosis. Extracellular proteoglycans …

Studies of pericytes have been retarded by the lack of appropriate markers for identification
of these perivascular mural cells. Use of antibodies against the NG2 proteoglycan as a …

Cancer cell behavior is not only governed by tumor cell-autonomous properties but also by
the surrounding tumor stroma. Cancer-associated fibroblasts, blood vessels, immune cells …

The NG2 proteoglycan stimulates the proliferation and migration of various immature cell
types, including pericytes. However, the role of NG2 in mediating pericyte/endothelial cell …

The Wnt̸β‑catenin signaling pathway plays a key role during hepatocellular carcinoma
(HCC) genesis and development. The present study aimed to investigate the effects of the …

Despite the significant progress in tumor prevention, early detection, diagnosis and
treatment made over recent decades, cancer is still an enormous public health challenge all …