Over the past few decades, research on Alzheimer's disease (AD) has focused on
pathomechanisms linked to two of the major pathological hallmarks of extracellular …

The discovery of the central role played by the protein alpha-synuclein in Parkinson's
disease and other Lewy body brain disorders has had a great relevance in the …

Neuroinflammation is one of the most important processes involved in the pathogenesis of
Parkinson's disease (PD). The current concept of neuroinflammation comprises an …

When cells undergo necrotic cell death in either physiological or pathophysiological settings
in vivo, they release highly immunogenic intracellular molecules and organelles into the …

In the first part, the following mechanisms involved in different forms of cell death are
considered, with a view to identifying potential therapeutic targets: tumour necrosis factor …

Approximately 30% of epilepsy patients experience seizures that are not controlled by the
available drugs. Moreover, these drugs provide mainly a symptomatic treatment since they …

The brain is both the orchestrator as well as the target of the innate immune system's
response to the aseptic trauma of surgery. When trauma-induced inflammation is not …

Background Growing evidence suggests an association between Parkinson's disease (PD)
and diabetes mellitus (DM). At the cellular level, long-term elevated levels of glucose have …

Mitochondrial dysfunction has been established as a common feature of neurodegenerative
disorders that contributes to disease pathology by causing impaired cellular energy …

Lysosomal storage diseases (LSDs) include approximately 70 distinct disorders that
collectively account for 14% of all inherited metabolic diseases. LSDs are caused by …