Development of the human placenta
MY Turco, A Moffett - Development, 2019 - journals.biologists.com
The placenta is essential for normal in utero development in mammals. In humans, defective
placental formation underpins common pregnancy disorders such as pre-eclampsia and …
placental formation underpins common pregnancy disorders such as pre-eclampsia and …
Human placenta and trophoblast development: key molecular mechanisms and model systems
M Knöfler, S Haider, L Saleh, J Pollheimer… - Cellular and Molecular …, 2019 - Springer
Abnormal placentation is considered as an underlying cause of various pregnancy
complications such as miscarriage, preeclampsia and intrauterine growth restriction, the …
complications such as miscarriage, preeclampsia and intrauterine growth restriction, the …
Pluripotent stem cell-derived model of the post-implantation human embryo
BAT Weatherbee, CW Gantner, LK Iwamoto-Stohl… - Nature, 2023 - nature.com
The human embryo undergoes morphogenetic transformations following implantation into
the uterus, but our knowledge of this crucial stage is limited by the inability to observe the …
the uterus, but our knowledge of this crucial stage is limited by the inability to observe the …
Blastocyst-like structures generated from human pluripotent stem cells
Limited access to embryos has hampered the study of human embryogenesis and disorders
that occur during early pregnancy. Human pluripotent stem cells provide an alternative …
that occur during early pregnancy. Human pluripotent stem cells provide an alternative …
A human cell atlas of fetal gene expression
INTRODUCTION A reference atlas of human cell types is a major goal for the field. Here, we
set out to generate single-cell atlases of both gene expression (this study) and chromatin …
set out to generate single-cell atlases of both gene expression (this study) and chromatin …
Modelling human blastocysts by reprogramming fibroblasts into iBlastoids
Human pluripotent and trophoblast stem cells have been essential alternatives to
blastocysts for understanding early human development 1, 2, 3, 4. However, these simple …
blastocysts for understanding early human development 1, 2, 3, 4. However, these simple …
Construction of a human cell landscape at single-cell level
Single-cell analysis is a valuable tool for dissecting cellular heterogeneity in complex
systems. However, a comprehensive single-cell atlas has not been achieved for humans …
systems. However, a comprehensive single-cell atlas has not been achieved for humans …
Naive stem cell blastocyst model captures human embryo lineage segregation
Human naive pluripotent cells can differentiate into extraembryonic trophectoderm and
hypoblast. Here we describe a human embryo model (blastoid) generated by self …
hypoblast. Here we describe a human embryo model (blastoid) generated by self …
Capturing human trophoblast development with naive pluripotent stem cells in vitro
S Io, M Kabata, Y Iemura, K Semi, N Morone… - Cell stem cell, 2021 - cell.com
Trophoblasts are extraembryonic cells that are essential for maintaining pregnancy. Human
trophoblasts arise from the morula as trophectoderm (TE), which, after implantation …
trophoblasts arise from the morula as trophectoderm (TE), which, after implantation …
Initiation of a conserved trophectoderm program in human, cow and mouse embryos
C Gerri, A McCarthy, G Alanis-Lobato, A Demtschenko… - Nature, 2020 - nature.com
Current understandings of cell specification in early mammalian pre-implantation
development are based mainly on mouse studies. The first lineage differentiation event …
development are based mainly on mouse studies. The first lineage differentiation event …