Abstract The phosphatidylinositol 3-kinase (PI3K)/Akt pathway plays a crucial role in various
cellular processes and is aberrantly activated in cancers, contributing to the occurrence and …

Colorectal cancer (CRC) is the third most common cancer and the second leading cause of
cancer-related death worldwide. Countless CRC patients undergo disease progression. As …

Colorectal cancer has served as a genetic and biological paradigm for the evolution of solid
tumors, and these insights have illuminated early detection, risk stratification, prevention …

Abstract The United States Food and Drug Administration (US FDA) has always been a
forerunner in drug evaluation and supervision. Over the past 31 years, 1050 drugs …

Targeted degradation of cell surface and extracellular proteins via lysosomal delivery is an
important means to modulate extracellular biology. However, these approaches have …

This portion of the NCCN Guidelines for Colon Cancer focuses on the use of systemic
therapy in metastatic disease. Considerations for treatment selection among 32 different …

Interlocking gene mutations, epigenetic alterations and microenvironmental features
perpetuate tumor development, growth, infiltration and spread. Consequently, intrinsic and …

The mitogen-activated extracellular signal-regulated kinase (MEK) pathway is one of the
best-characterized kinase cascades in cancer cell biology. It is triggered by either growth …

The huge part of population in developed countries is overweight or obese. Obesity is often
determined by body mass index (BMI) but new accurate methods and ratios have recently …

The NCCN Guidelines for Colon Cancer address diagnosis, pathologic staging, surgical
management, perioperative treatment, posttreatment surveillance, management of recurrent …