The blood compatibility challenge. Part 2: Protein adsorption phenomena governing blood reactivity

JL Brash, TA Horbett, RA Latour, P Tengvall - Acta biomaterialia, 2019 - Elsevier
The adsorption of proteins is the initiating event in the processes occurring when blood
contacts a “foreign” surface in a medical device, leading inevitably to thrombus formation …

Contact system: a vascular biology modulator with anticoagulant, profibrinolytic, antiadhesive, and proinflammatory attributes

RW Colman, AH Schmaier - … Journal of the American Society of …, 1997 - ashpublications.org
Gene expression and regulation. The two forms of a prolonged activated partial
thromboplastin time (APTT), plasma kininogens, HK and low molecular weight kininogen a …

Fibrinogen adsorption to biomaterials

TA Horbett - Journal of biomedical materials research Part A, 2018 - Wiley Online Library
Fibrinogen (Fg) adsorption is an important mechanism underlying cell adhesion to
biomaterials and was the major focus of the author's research career. This article …

Protein adsorption from human plasma is reduced on phospholipid polymers

K Ishihara, NP Ziats, BP Tierney… - Journal of …, 1991 - Wiley Online Library
Protein adsorption from human plasma was investigated on phospholipid polymers, poly (2‐
methacryloyloxyethyl phos‐phorylcholine (MPC)‐co‐n‐butyl methacrylate (BMA)) or glass …

Cardiac vasoplegia syndrome: pathophysiology, risk factors and treatment

S Omar, A Zedan, K Nugent - The American journal of the medical sciences, 2015 - Elsevier
Vasoplegia syndrome is a well known complication after cardiac surgery and has a
significant morbidity and mortality. It is characterized by profound vasodilation and loss of …

Polypeptide growth factors: targeted delivery systems

ME Nimni - Biomaterials, 1997 - Elsevier
Growth factors are becoming extremely valuable tools in our attempts to understand the
mechanisms that modulate cellular activities. Their targeting to appropriate cells and …

Proteins at interfaces: an overview

JL Brash, TA Horbett - 1995 - ACS Publications
Proteins at interfaces are involved in a wide variety of phenomena, including mammalian
cell growth in culture, reactions to implanted biomaterials, growth of soil bacteria, and …

Fifty years of research on the plasma kallikrein-kinin system: from protein structure and function to cell biology and in-vivo pathophysiology

IM Sainz, RA Pixley, RW Colman - Thrombosis and …, 2007 - thieme-connect.com
F or forty years my laboratory has been studying the kallikrein-kininogen-kinin system (KKS).
I was challenged by my mentor Dr. Sol Sherry in whose laboratory I was completing my …

Serum protein adsorption and platelet adhesion on pluronic™-adsorbed polysulfone membranes

A Higuchi, K Sugiyama, BO Yoon, M Sakurai, M Hara… - Biomaterials, 2003 - Elsevier
We examined plasma protein adsorption and platelet adhesion to polysulfone (PSf) flat
membranes coated with Pluronic™ with varying polyethylene oxide (PEO) block length …

A microfluidics device to monitor platelet aggregation dynamics in response to strain rate micro-gradients in flowing blood

FJ Tovar-Lopez, G Rosengarten, E Westein… - Lab on a Chip, 2010 - pubs.rsc.org
This paper reports the development of a platform technology for measuring platelet function
and aggregation based on localized strain rate micro-gradients. Recent experimental …