In recent years, major advances have been made in cancer immunotherapy. This has led to
significant improvement in prognosis of cancer patients, especially in the hematological …

Proteasome inhibitors are one of the most important classes of agents to have emerged for
the treatment of multiple myeloma in the past two decades, and now form one of the …

The Wnt signaling pathway plays important roles in embryonic development, homeostatic
processes, cell differentiation, cell polarity, cell proliferation, and cell migration via the β …

Epstein–Barr virus-associated diseases are important global health concerns. As a group I
carcinogen, EBV accounts for 1.5% of human malignances, including both epithelial-and …

Regarding the crucial role of deubiquitinase (DUB) enzymes in many viruses, in particular,
Adenovirus, HSV-1, coxsackievirus, and SARS-CoV-2, DUB inhibition was reported as an …

Background: Despite years of success of most anti-cancer drugs, one of the major clinical
problems is inherent and acquired resistance to these drugs. Overcoming the drug …

Papillary thyroid carcinoma (PTC) is the main type of thyroid carcinoma. Despite the good
prognosis, some PTC patients may deteriorate into more aggressive diseases, leading to …

Yes-associated protein (YAP) is one of major key effectors of the Hippo pathway and the
mechanism supporting abnormal YAP expression in Anaplastic thyroid carcinoma (ATC) …

Abstract Background Cancer-associated fibroblasts (CAFs), the predominant stromal cell of
tumor microenvironment (TME), play an important role in tumor progression and …

The reversible post‐translational modification of proteins by ubiquitin and ubiquitin‐like
proteins regulates almost all cellular processes, by affecting protein degradation …