Inflammation and resolution signaling in cardiac repair and heart failure

GV Halade, DH Lee - EBioMedicine, 2022 - thelancet.com
Unresolved inflammation is a key mediator of advanced heart failure. Especially, damage,
pathogen, and lifestyle-associated molecular patterns are the major factors in initiating …

[HTML][HTML] Extracellular vesicles, the emerging mirrors of brain physiopathology

A Cano, M Ettcheto, M Bernuz, R Puerta… - … journal of biological …, 2023 - ncbi.nlm.nih.gov
Extracellular vesicles are secreted by a wide variety of cells, and their primary functions
include intercellular communication, immune responses, human reproduction, and synaptic …

[HTML][HTML] Injectable conductive gelatin methacrylate/oxidized dextran hydrogel encapsulating umbilical cord mesenchymal stem cells for myocardial infarction treatment

S Zhu, C Yu, N Liu, M Zhao, Z Chen, J Liu, G Li… - Bioactive materials, 2022 - Elsevier
Umbilical cord mesenchymal stem cells (UCMSCs) transplantation has been proposed as a
promising treatment modality for myocardial infarction (MI), but the low retention rate …

[HTML][HTML] Efferocytes release extracellular vesicles to resolve inflammation and tissue injury via prosaposin-GPR37 signaling

P Bhattacharya, UK Dhawan, MT Hussain, P Singh… - Cell reports, 2023 - cell.com
Macrophages release soluble mediators following efferocytic clearance of apoptotic cells to
facilitate intercellular communication and promote the resolution of inflammation. However …

Biodelivery of therapeutic extracellular vesicles: should mononuclear phagocytes always be feared?

M Cieślik, K Bryniarski, K Nazimek - Frontiers in Cell and …, 2023 - frontiersin.org
At present, extracellular vesicles (EVs) are considered key candidates for cell-free therapies,
including treatment of allergic and autoimmune diseases. However, their therapeutic …

Communications between macrophages and cardiomyocytes

P Yang, Z Chen, W Huang, J Zhang, L Zou… - Cell Communication and …, 2023 - Springer
The heart is a muscular organ that pumps blood throughout the body and is one of the most
vital organs in human body. While cardiomyocytes are essential for maintaining the normal …

A Review of Extracellular Vesicles in COVID‐19 Diagnosis, Treatment, and Prevention

P Su, Y Wu, F Xie, Q Zheng, L Chen, Z Liu… - Advanced …, 2023 - Wiley Online Library
The 2019 novel coronavirus disease (COVID‐19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is ongoing, and has necessitated …

Human keratinocyte-derived exosomal MALAT1 promotes diabetic wound healing by upregulating MFGE8 via microRNA-1914-3p

L Kuang, C Zhang, B Li, H Deng… - International journal of …, 2023 - Taylor & Francis
Purpose Diabetic wound is a highly prevalent and refractory disease. Extensive studies
have confirmed that keratinocytes and macrophages play an important role in the process of …

Colorectal cancer-derived extracellular vesicles containing HSP70 enhance macrophage phagocytosis by up-regulating MARCO expression

Y Sun, W Xiao, Y Yu, Y Jiang, Z Xiao, D Huang… - Experimental Cell …, 2023 - Elsevier
In recent years, we have realized that extracellular vesicles (EVs) play a critical role in
regulating the intercellular communication between tumor and immune cells in the tumor …

From novel discovery tools and biomarkers to precision medicine—basic cardiovascular science highlights of 2021/22

PC Evans, SM Davidson, J Wojta, M Bäck… - Cardiovascular …, 2022 - academic.oup.com
Here, we review the highlights of cardiovascular basic science published in 2021 and early
2022 on behalf of the European Society of Cardiology Council for Basic Cardiovascular …