Bacteriophages, also known as phages, are specific antagonists against bacteria. T7 phage
has drawn massive attention in precision medicine owing to its distinctive advantages, such …

Sixty years after Hershey and Chase showed that nucleic acid is the major component of
phage particles that is ejected into cells, we still do not fully understand how the process …

Adsorption and genome ejection are fundamental to the bacteriophage life cycle, yet their
molecular mechanisms are not well understood. We used cryo–electron tomography to …

The SAR11 clade are the most abundant members of surface marine bacterioplankton and a
critical component of global biogeochemical cycles. Similarly, pelagiphages that infect …

For successful infection, bacteriophages must overcome multiple barriers to transport their
genome and proteins across the bacterial cell envelope. We use cryo-electron tomography …

In 1952, Hershey and Chase used bacteriophage T2 genome delivery inside Escherichia
coli to demonstrate that DNA, not protein, is the genetic material. Over 70 years later, our …

Tailed dsDNA bacteriophage virions bind to susceptible cells with the tips of their tails and
then deliver their DNA through the tail into the cells to initiate infection. This chapter …

In this chapter, we describe the structure, assembly, function, and evolution of the long,
noncontractile tail of the siphophages, which comprise∼ 60% of the phages on earth. We …

The emergence of antibiotic resistance has raised serious concerns within scientific and
medical communities, and has underlined the importance of developing new antimicrobial …

To infect, a virion must first encounter a bacterium, where “encounter” essentially is a
euphemism for “collision.” That is, a virion must physically touch a target bacterium to enable …