Critical role of microRNA-21 in the pathogenesis of liver diseases
MicroRNAs are small non-coding RNAs that range in length from 18 to 24 nucleotides. As
one of the most extensively studied microRNAs, microRNA-21 (miR-21) is highly expressed …
one of the most extensively studied microRNAs, microRNA-21 (miR-21) is highly expressed …
Molecular and tissue alterations of collagens in fibrosis
S Ricard-Blum, G Baffet, N Théret - Matrix Biology, 2018 - Elsevier
The collagen network is altered in fibrotic diseases associated with extracellular matrix
(ECM) biosynthesis and remodeling. This mini-review focuses on the quantitative and …
(ECM) biosynthesis and remodeling. This mini-review focuses on the quantitative and …
Interaction between alcohol consumption and metabolic syndrome in predicting severe liver disease in the general population
F Åberg, J Helenius‐Hietala, P Puukka, M Färkkilä… - Hepatology, 2018 - journals.lww.com
Several staging systems for hepatocellular carcinoma (HCC) have been developed. The
Barcelona Clinic Liver Cancer staging system is considered the best in predicting survival …
Barcelona Clinic Liver Cancer staging system is considered the best in predicting survival …
miR‐21‐5p promotes NASH‐related hepatocarcinogenesis
Abstract Background and Aims The mechanisms governing the progression of non‐
alcoholic fatty liver disease (NAFLD) towards steatohepatitis (NASH) and hepatocellular …
alcoholic fatty liver disease (NAFLD) towards steatohepatitis (NASH) and hepatocellular …
microRNA-21, via the HIF-1α/VEGF signaling pathway, is involved in arsenite-induced hepatic fibrosis through aberrant cross-talk of hepatocytes and hepatic stellate …
J Sun, L Shi, T Xiao, J Xue, J Li, P Wang, L Wu, X Dai… - Chemosphere, 2021 - Elsevier
Long-term exposure to arsenic, a widely distributed environmental toxicant, may result in
damage to various organs, including the liver. Mice exposed chronically to arsenite …
damage to various organs, including the liver. Mice exposed chronically to arsenite …
miRNA-21 ablation protects against liver injury and necroptosis in cholestasis
MB Afonso, PM Rodrigues, AL Simão… - Cell Death & …, 2018 - nature.com
Abstract Inhibition of microRNA-21 (miR-21) prevents necroptosis in the mouse pancreas.
Necroptosis contributes to hepatic necro-inflammation in the common bile duct ligation …
Necroptosis contributes to hepatic necro-inflammation in the common bile duct ligation …
Secretin alleviates biliary and liver injury during late-stage primary biliary cholangitis via restoration of secretory processes
Background & Aims Primary biliary cholangitis (PBC) is characterised by ductopenia,
ductular reaction, impairment of anion exchanger 2 (AE2) and the 'bicarbonate umbrella' …
ductular reaction, impairment of anion exchanger 2 (AE2) and the 'bicarbonate umbrella' …
A large‐scale multicenter study validates aldo‐keto reductase family 1 member B10 as a prevalent serum marker for detection of hepatocellular carcinoma
X Ye, C Li, X Zu, M Lin, Q Liu, J Liu, G Xu, Z Chen… - Hepatology, 2019 - journals.lww.com
Cholangiopathies are diseases that affect cholangiocytes, the cells lining the biliary tract.
Liver stem cells (LSCs) are able to differentiate into all cells of the liver and possibly …
Liver stem cells (LSCs) are able to differentiate into all cells of the liver and possibly …
[PDF][PDF] MicroRNA‐21 and Dicer are dispensable for hepatic stellate cell activation and the development of liver fibrosis
JM Caviglia, J Yan, MK Jang, GY Gwak, S Affo… - …, 2018 - Wiley Online Library
Fibrosis and cancer represent two major complications of chronic liver disease. MicroRNAs
have been implicated in the development of fibrosis and cancer, thus constituting potential …
have been implicated in the development of fibrosis and cancer, thus constituting potential …
MicroRNA-21 deficiency suppresses prostate cancer progression through downregulation of the IRS1-SREBP-1 signaling pathway
T Kanagasabai, G Li, TH Shen, N Gladoun… - Cancer letters, 2022 - Elsevier
Sterol regulatory element-binding protein 1 (SREBP-1), a master transcription factor in
lipogenesis and lipid metabolism, is critical for disease progression and associated with …
lipogenesis and lipid metabolism, is critical for disease progression and associated with …