Understanding kidney disease relies on defining the complexity of cell types and states, their
associated molecular profiles and interactions within tissue neighbourhoods. Here we …

Patients with chronic obstructive pulmonary disease (COPD) are at increased risk of
cardiovascular disease (CVD) and concomitant disease leads to reduced quality of life …

Chronic obstructive pulmonary disease (COPD) patients frequently suffer from multiple
comorbidities, resulting in poor outcomes for these patients. Diabetes is observed at a …

Background Clinical and epidemiologic studies have shown that obesity is associated with
asthma and that these associations differ by asthma subtype. Little is known about the …

The widespread comorbidity among psychiatric disorders demonstrated in epidemiological
studies,,,–is mirrored by non-zero, positive genetic correlations from large-scale genetic …

Epidemiological studies demonstrate an association between asthma and mental health
disorders, although little is known about the shared genetics and causality of this …

Background Lung function is a heritable complex phenotype with obesity being one of its
important risk factors. However, knowledge of their shared genetic basis is limited. Most …

To date only a fraction of the genetic footprint of thyroid function has been clarified. We
report a genome-wide association study meta-analysis of thyroid function in up to 271,040 …

Background The rapid accumulation of single-cell RNA sequencing (scRNA-seq) data
presents unique opportunities to decode the genetically mediated cell-type specificity in …

Moving in synchrony to the beat is a fundamental component of musicality. Here we
conducted a genome-wide association study to identify common genetic variants associated …