Ion channels play a central role in the regulation of nearly every cellular process. Dating
back to the classic 1952 Hodgkin–Huxley model of the generation of the action potential, ion …

Understanding voltage-gated sodium (Nav) channels is significant since they generate
action potential. Nav channels consist of a pore domain (PD) and a voltage sensor domain …

Abstract 1H detection can significantly improve solid‐state NMR spectral sensitivity and
thereby allows studying more complex proteins. However, the common prerequisite for 1H …

The most essential properties of ion channels for their physiologically relevant functions are
ion‐selective permeation and gating. Among the channel species, the potassium channel is …

Across biological systems, cooperativity between proteins enables fast actions, supra-linear
responses, and long-lasting molecular switches. In the nervous system, however, the …

KcsA is a potassium channel with a plethora of structural and functional information, but its
activity in the KcsA-producing actinomycete membranes remains elusive. To determine lipid …

The segregation of cellular surfaces in heterogeneous patches is considered to be a
common motif in bacteria and eukaryotes that is underpinned by the observation of …

Here, we have developed a method of oriented reconstitution of the KcsA potassium
channel amenable to high-resolution AFM imaging. The solubilized full-length KcsA …

Abstract Amphidinol 3 (AM3) is an anti-fungal polyene extracted from a marine
dinoflagellate. Here, we examined the ion channel activity and membrane-embedded …

The membrane environment, including specific lipid characteristics, plays important roles in
the folding, stability, and gating of the prokaryotic potassium channel KcsA. Here we study …