Maintenance of protein homeostasis and organelle integrity and function is critical for
cellular homeostasis and cell viability. Autophagy is the principal mechanism that mediates …

Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …

The major concept of" oxidative stress" is an excess elevated level of reactive oxygen
species (ROS) which are generated from vigorous metabolism and consumption of oxygen …

Autophagy, as a type II programmed cell death, plays crucial roles with autophagy-related
(ATG) proteins in cancer. Up to now, the dual role of autophagy both in cancer progression …

Autophagy is a regulated mechanism that removes unnecessary or dysfunctional cellular
components and recycles metabolic substrates. In response to stress signals in the tumour …

Efficient proteostasis is crucial for somatic maintenance, and its decline during aging leads
to cellular dysfunction and disease. Selective autophagy is a form of autophagy mediated by …

Autophagy causes the breakdown of damaged proteins and organelles to their constituent
components. The phosphatidylinositol 3‐kinase (PI3K) pathway played an important role in …

Macroautophagy (herein referred to as autophagy) is an evolutionary ancient mechanism
that culminates with the lysosomal degradation of superfluous or potentially dangerous …

The transcription factor NRF2 is the master regulator of the cellular antioxidant response.
Though recognized originally as a target of chemopreventive compounds that help prevent …

Aims/hypothesis: SGLT-2 inhibitors (SGLT-2i) have been studied as potential treatments
against NAFLD, showing varying beneficial effects. The molecular mechanisms mediating …