Genomic instability is the hallmark of various cancers with the increasing accumulation of
DNA damage. The application of radiotherapy and chemotherapy in cancer treatment is …

The cells in the human body are continuously challenged by a variety of genotoxic attacks.
Erroneous repair of the DNA can lead to mutations and chromosomal aberrations that can …

Cisplatin, carboplatin and oxaliplatin are platinum-based drugs that are widely used in
cancer chemotherapy. Platinum–DNA adducts, which are formed following uptake of the …

As the tale of p53 unfolds, it becomes ever more intriguing. Although our understanding of
the critical and complex roles played by p53 is progressing rapidly, new findings continue to …

p53 protects against cancer through its capacity to induce cell cycle arrest or apoptosis
under a large variety of cellular stresses. It is not known how such diversity of signals can be …

Cell division and organismal development are exquisitely orchestrated and regulated
processes. The dysregulation of the molecular mechanisms underlying these processes …

The p53 gene is frequently inactivated in human cancers. Here we have isolated a p53-
inducible gene, p53R2, by using differential display to examine messenger RNAs in a …

The human genome, comprising three billion base pairs coding for 30000–40000 genes, is
constantly attacked by endogenous reactive metabolites, therapeutic drugs and a plethora of …

From its modest beginnings in 1979, as a transformation-associated protein, to the
discoveries that p53 plays a key role in tumour suppression and in the cellular response to …

Two systems are essential in humans for genome integrity, DNA repair and apoptosis. Cells
that are defective in DNA repair tend to accumulate excess DNA damage. Cells defective in …