DNA damage response (DDR) is critical to ensure genome stability, and defects in this
signaling pathway are highly associated with carcinogenesis and tumor progression …

Steroid hormone signaling induces vast gene expression programs which necessitate the
local formation of transcription factories at regulatory regions and large-scale alterations of …

PURPOSE Uterine serous carcinoma (USC) is a distinct histologic subtype of endometrial
cancer, with molecular characteristics suggesting frequent cell-cycle dysregulation paired …

PURPOSE Preclinical cancer models harboring CCNE1 amplification were more sensitive to
adavosertib treatment, a WEE1 kinase inhibitor, than models without amplification. Thus, we …

Summary Background Next Generation Sequencing (NGS) panels are increasingly used in
advanced patients with cancer to guide therapy. There is, however, controversy about when …

Neuroendocrine neoplasms (NENs), which are characterized by neuroendocrine
differentiation, can arise in various organs. NENs have been divided into well-differentiated …

PURPOSE To provide evidence-based recommendations to practicing clinicians on the
management of patients with small-cell lung cancer. METHODS An Expert Panel of medical …

Alterations in mTOR signalling molecules, including RICTOR amplification, have been
previously described in many cancers, particularly associated with poor prognosis. In this …

Background AZD2811 is a potent, selective Aurora kinase B inhibitor. We report the dose-
escalation phase of a first-in-human study assessing nanoparticle-encapsulated AZD2811 …

Despite advancements in cancer management, tumor relapse and metastasis are
associated with poor outcomes in many cancers. Over the past decade, oncogene-driven …