TFOS DEWS II pain and sensation report
Pain associated with mechanical, chemical, and thermal heat stimulation of the ocular
surface is mediated by trigeminal ganglion neurons, while cold thermoreceptors detect …
surface is mediated by trigeminal ganglion neurons, while cold thermoreceptors detect …
Neurotrophic keratopathy
HS Dua, DG Said, EM Messmer, M Rolando… - Progress in retinal and …, 2018 - Elsevier
Neurotrophic Keratopathy (NK) refers to a condition where corneal epitheliopathy leading to
frank epithelial defect with or without stromal ulceration (melting) is associated with reduced …
frank epithelial defect with or without stromal ulceration (melting) is associated with reduced …
Neuroimmune crosstalk in the cornea: The role of immune cells in corneal nerve maintenance during homeostasis and inflammation
In the cornea, resident immune cells are in close proximity to sensory nerves, consistent with
their important roles in the maintenance of nerves in both homeostasis and inflammation …
their important roles in the maintenance of nerves in both homeostasis and inflammation …
Neutrophil extracellular traps (NETs) contribute to pathological changes of ocular graft-vs.-host disease (oGVHD) dry eye: Implications for novel biomarkers and …
Purpose To investigate the role of neutrophil extracellular traps (NETs) and NET-associated
proteins in the pathogenesis of oGVHD and whether dismantling of NETs with heparin …
proteins in the pathogenesis of oGVHD and whether dismantling of NETs with heparin …
Corneal epithelial cells function as surrogate Schwann cells for their sensory nerves
MA Stepp, G Tadvalkar, R Hakh, S Pal‐Ghosh - Glia, 2017 - Wiley Online Library
The eye is innervated by neurons derived from both the central nervous system and
peripheral nervous system (PNS). While much is known about retinal neurobiology and …
peripheral nervous system (PNS). While much is known about retinal neurobiology and …
[HTML][HTML] Dendritic cell dysfunction and diabetic sensory neuropathy in the cornea
N Gao, C Yan, P Lee, H Sun… - The Journal of clinical …, 2016 - Am Soc Clin Investig
Diabetic peripheral neuropathy (DPN) often leads to neurotrophic ulcerations in the cornea
and skin; however, the underlying cellular mechanisms of this complication are poorly …
and skin; however, the underlying cellular mechanisms of this complication are poorly …
[HTML][HTML] Intraepithelial dendritic cells and sensory nerves are structurally associated and functional interdependent in the cornea
N Gao, P Lee, FS Yu - Scientific reports, 2016 - nature.com
The corneal epithelium consists of stratified epithelial cells, sparsely interspersed with
dendritic cells (DCs) and a dense layer of sensory axons. We sought to assess the structural …
dendritic cells (DCs) and a dense layer of sensory axons. We sought to assess the structural …
Topical formulations of Aprepitant are safe and effective in relieving pain and inflammation, and drive neural regeneration
Purpose To test long-term ocular toxicity and analgesic/anti-inflammatory efficacy of two
novel ocular formulations of neurokinin 1 receptor (NK1R) antagonist Aprepitant. Methods …
novel ocular formulations of neurokinin 1 receptor (NK1R) antagonist Aprepitant. Methods …
[HTML][HTML] Intravital multiphoton microscopy of the ocular surface: alterations in conventional dendritic cell morphology and kinetics in dry eye disease
Dry eye disease (DED) is a multifactorial disease of the ocular surface, characterized by loss
of tear film homeostasis and ocular symptoms, in which neurosensory abnormalities have …
of tear film homeostasis and ocular symptoms, in which neurosensory abnormalities have …
The miR-183/96/182 cluster is a checkpoint for resident immune cells and shapes the cellular landscape of the cornea
Abstract Purpose The conserved miR-183/96/182 cluster (miR-183C) regulates both corneal
sensory innervation and corneal resident immune cells (CRICs). This study is to uncover its …
sensory innervation and corneal resident immune cells (CRICs). This study is to uncover its …